洋红霉素

洋红霉素用途

胡萝卜素(Carminomycin)是一种微生物衍生的化合物。胡萝卜素是VHL缺陷型(VHL)的有效抑制剂−/−) CCRCC细胞增殖。胡萝卜素也通过一种独立于p53或缺氧诱导因子HIF2的机制诱导细胞凋亡。胡萝卜素具有研究癌症疾病的潜力[1][2]。

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洋红霉素名称

[ CAS 号 ]:
50935-04-1

[ 中文名 ]:
卡米诺霉素

[ 英文名 ]:
Carubicin

[中文别名 ]:

洋红霉素

[英文别名 ]:

Carminomycin
Carminomycin I
Antibiotic R-588A
Carminomicin I
Karminomitsin
4-O-Demethyldaunorubicin
Karminomycin
Carubicin

洋红霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

[参考文献]

[1]. [1]Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42.

洋红霉素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
750.6±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₆H₂₇NO₁₀

[ 分子量 ]:
513.493

[ 闪点 ]:
407.7±32.9 °C

[ 精确质量 ]:
513.163513

[ PSA ]:
196.84000

[ LogP ]:
3.54

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.727

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

洋红霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9293250

CHEMICAL NAME :: 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hex opyranosyl)oxy)- 7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-

CAS REGISTRY NUMBER :: 50935-04-1

LAST UPDATED :: 199406

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C26-H27-N-O10

MOLECULAR WEIGHT :: 513.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7250 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 490 nmol/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1596,1981

洋红霉素

洋红霉素用途

洋红霉素名称

洋红霉素生物活性

洋红霉素物理化学性质

洋红霉素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

洋红霉素合成路线

详细合成路线

洋红霉素上下游产品

洋红霉素上游产品

洋红霉素下游产品

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