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离子霉素

离子霉素用途

Ionomycin 是一个钙离子载体 (Calcium ionophore),也是来源于链霉菌属 (Streptomyces conglobatus ATCC 31005) 的一种抗生素。

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离子霉素名称

[ CAS 号 ]:
56092-81-0

[ 中文名 ]:
罗红霉素

[ 英文名 ]:
Ionomycin

[中文别名 ]:

离子霉素

[英文别名 ]:

Ionomycin
Ionomycin,Free Acid,from Streptomyces conglbatus
MFCD00036890
Ionomycinefreeacid
Ionomycin from Streptomyces conglobatus
IONOMYCIN,STREPTOMYCES CONGLOBATUS
Ionomycin free acid
Ionomycin,Free Acid,Streptomyces conglobatus

离子霉素生物活性

[ 描述 ]:

Ionomycin 是一个钙离子载体 (Calcium ionophore),也是来源于链霉菌属 (Streptomyces conglobatus ATCC 31005) 的一种抗生素。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 癌症

研究领域 >> 感染

[ 靶点 ]

Calcium channel[1].

[体外研究]

离子霉素是一种钙离子载体和由Streptomyces conglobatus ATCC 31005产生的抗生素[1]。观察到过量表达μ-钙蛋白酶的催化亚基的LCLC 103H细胞在用离子霉素处理后迅速经历细胞死亡。在加入离子载体后3小时检测到离子霉素诱导的细胞死亡的最初迹象。向LCLC 103H细胞中加入2μM离子霉素导致细胞内Ca 2+浓度瞬间增加50至180nM。值得注意的是,钙浓度瞬间升高至0.8-1.5μM。在离子霉素处理的培养物中的DNA和蛋白质分析显示DNA片段化和PARP切割成典型的半胱天冬酶介导的细胞凋亡的85kDa片段。加入离子霉素3小时后,早期凋亡细胞的百分比大约翻倍。在同时阳性荧光素标记和碘化丙锭摄取的支持下,可以在~1-5％的离子霉素处理的细胞中检测到坏死。在全细胞中Caspase活化后,监测离子霉素处理后抗Ac-DEVD-amc活性的增加[2]。

[参考文献]

[1]. Liu C, et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.

[2]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.

[相关活性小分子]

离子霉素物理化学性质

[ 密度 ]:
1.072 g/cm3

[ 沸点 ]:
817.2ºC at 760 mmHg

[ 分子式 ]:
C₄₁H₇₂O₉

[ 分子量 ]:
709.00500

[ 闪点 ]:
235.2ºC

[ 精确质量 ]:
708.51800

[ PSA ]:
153.75000

[ LogP ]:
7.79960

[ 外观性状 ]:
淡黄色油状

[ 折射率 ]:
1.512

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble to 10 mM in Ethanol and to 10 mM in DMSO.

离子霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NO0600000

CHEMICAL NAME :: Ionomycin

CAS REGISTRY NUMBER :: 56092-81-0

LAST UPDATED :: 199107

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C41-H70-O9

MOLECULAR WEIGHT :: 707.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,815,1978

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离子霉素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36-36/37/39-27-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NO0650000

[ 海关编码 ]:
2941500000

离子霉素合成路线

详细合成路线

离子霉素上下游产品

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离子霉素下游产品

离子霉素海关

[ 海关编码 ]: 2941500000

离子霉素文献

Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.

Am. J. Physiol. Endocrinol. Metab. 307(2) , E209-24, (2014)

Elevating cytosolic Ca(2+) stimulates glucose uptake in skeletal muscle, but how Ca(2+) affects intracellular traffic of GLUT4 is unknown. In tissue, changes in Ca(2+) leading to contraction preclude ...

Regulation of T cell priming by lymphoid stroma.

PLoS ONE 6(11) , e26138, (2011)

The priming of immune T cells by their interaction with dendritic cells (DCs) in lymph nodes (LN), one of the early events in productive adaptive immune responses, occurs on a scaffold of lymphoid str...

Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood.

J. Exp. Med. 206(5) , 1009-17, (2009)

Two subsets of natural and adaptive regulatory T (T reg) cells have been described, but the identity of adaptive type 1 regulatory (Tr1)-like cells in humans is unclear. We analyzed a subset of human ...

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