手霉素A

手霉素A用途

Manumycin A 是一种抗生素。Manumycin A 作为一种选择性、竞争性的 farnesyltransferase (FTase) 抑制剂,与 farnesylpyrophosphate (Ki =1.2 μM) 有关,并且作为 Ras 蛋白质的非竞争性抑制剂。Manumycin A 诱导细胞凋亡并发挥抗肿瘤活性。

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手霉素A名称

[ CAS 号 ]:
52665-74-4

[ 中文名 ]:
手霉素A,从链霉菌得来

[ 英文名 ]:
Manumycin A

[中文别名 ]:

手霉素A

[英文别名 ]:

Manumycin A
MFCD00920782

手霉素A生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯

信号通路 >> 代谢酶/蛋白酶 >> 法呢基转移酶

[ 靶点 ]

Farnesyltransferase, Ras[1]

[参考文献]

[1]. Hara M, et al. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2281-5.

[2]. Bernier M, et al. Binding of manumycin A inhibits IkappaB kinase beta activity. J Biol Chem. 2006 Feb 3;281(5):2551-61.

[3]. Kim KH, et al. Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway. Oncol Rep. 2016 Jul;36(1):117-24.

手霉素A物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
863.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₁H₃₈N₂O₇

[ 分子量 ]:
550.643

[ 闪点 ]:
476.1±34.3 °C

[ 精确质量 ]:
550.267883

[ PSA ]:
145.33000

[ LogP ]:
3.04

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.605

[ 储存条件 ]:
2-8°C

手霉素A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

手霉素A文献

Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans.

Proc. Natl. Acad. Sci. U. S. A. 106(43) , 18285-90, (2009)

Statins are compounds prescribed to lower blood cholesterol in millions of patients worldwide. They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway that leads t...

[Effects of manumycin combined with methoxyamine on apoptosis in myeloid leukemia U937 cells].

Chin. J. Cancer 27(8) , 835-9, (2008)

Repair of DNA damage is important to cell survival. Our previous study showed DNA damage response induced by manumycin in cancer cells. We hypothesized that methoxyamine, an inhibitor of base-excision...

Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.

Biochimie 92(12) , 1934-8, (2010)

Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding lectin, has been reported to display remarkable anti-proliferative and apoptosis-inducing activities toward a variety of cancer cells;...

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