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硝酸硫胺

硝酸硫胺用途

Thiamine nitrate 是必不可少的维生素,能增强正常的神经元活性。

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硝酸硫胺名称

[ CAS 号 ]:
532-43-4

[ 中文名 ]:
硝酸硫胺

[ 英文名 ]:
Thiamine nitrate

[中文别名 ]:

维生素B1硝酸盐

[英文别名 ]:

EINECS 208-537-4
MFCD00036330
Thiamin mononitrate
Thiaminenitrate
thiamin nitrate
Thiamine nitrate,Vitamin B1 nitrate
Vitamin B1 Mono
thiamine,nitrate
Vitamin B1 nitrate
Thiamine Nitrate

硝酸硫胺生物活性

[ 描述 ]:

Thiamine nitrate 是必不可少的维生素,能增强正常的神经元活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

与WT小鼠(0.796±0.259μM)相比,喂食常规饮食的纯合KO和KI小鼠血液中的硫胺素水平分别在7周时降低至0.058±0.051和0.126±0.092μM。当WT和纯合KO和KI小鼠喂食硫胺素限制饮食(硫胺素：0.60 mg/100 g食物)时,血清硫胺素浓度在第5天和第14天分别显着降低至0.010±0.009和0.010±0.006μM, WT小鼠(0.609±0.288μM)。喂食常规饮食的WT小鼠脑匀浆中的硫胺素浓度为3.81±2.18nmol/g湿重,KO和KI的浓度分别为1.33±0.96和2.16±1.55nmol/g湿重。值得注意的是,在喂食硫胺素限制饮食(硫胺素：0.60 mg/100 g食品)5天(0.95±0.72 nmol/g湿重)和14天(1.11±0.24)的KO和KI小鼠中,脑匀浆中的硫胺素浓度稳定下降。在呈现疾病表型的小鼠之前,分别与WT(3.65±1.02nmol/g湿重)比较nmol/g湿重[2]。

[体内研究]

喂食常规饮食(硫胺素：1.71mg/100g)的WT,纯合和杂合KO和KI小鼠存活超过6个月而没有任何疾病表型。喂食硫胺素限制饮食的纯合KO和KI小鼠(硫胺素：0.60mg/100g食物)显示麻痹,体重减轻和不动,并且分别在12和30天内死亡。类似地,喂食硫胺限制饮食的纯合KO和KI小鼠分别在14天和18天内死亡,其中硫胺素(硫胺素：0.27mg/100g食物)的百分比甚至更低。然而,喂食硫胺限制饮食的WT和杂合KO和KI小鼠(硫胺素：0.60mg或0.27mg/100g食物)存活超过6个月而没有任何疾病表型[2]。

[动物实验]

Slc19a3 E314Q KI小鼠常规维持常规饮食，其具有1.71mg / 100g食物的硫胺素浓度（盐酸硫胺素，MW = 337.3）。根据“实验室啮齿动物的纯化日粮”制备两种硫胺素限制食品，其中硫胺素浓度为0.60 mg / 100 g食品（35％常规食品硫胺素）或0.27 mg / 100 g食品（16％硫胺素）传统食品）。含有高硫胺素的食物也是由AIN-93M制备的，其中硫胺素浓度是CE-2的5倍（硫胺素：8.50mg / 100g食物）[2]。

[参考文献]

[1]. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32.

[2]. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279.

[相关活性小分子]

硝酸硫胺物理化学性质

[ 熔点 ]:
196-200°C

[ 分子式 ]:
C₁₂H₁₇N₅O₄S

[ 分子量 ]:
327.359

[ 精确质量 ]:
327.100128

[ PSA ]:
173.03000

[ LogP ]:
1.47300

[ 外观性状 ]:
白色晶体粉末

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

硝酸硫胺MSDS

详细MSDS(安全技术说明书)

硝酸硫胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI7400000

CHEMICAL NAME :: Thiamine, nitrate

CAS REGISTRY NUMBER :: 532-43-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H17-N4-O-S.N-O3

MOLECULAR WEIGHT :: 327.40

WISWESSER LINE NOTATION :: T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 387 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80545 No. of Facilities: 177 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 15363 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80545 No. of Facilities: 1106 (estimated) No. of Industries: 8 No. of Occupations: 36 No. of Employees: 39898 (estimated) No. of Female Employees: 18813 (estimated)

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硝酸硫胺安全信息

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
XI7400000

[ 海关编码 ]:
2934100090

硝酸硫胺合成路线

详细合成路线

硝酸硫胺上下游产品

硝酸硫胺上游产品

硝酸硫胺下游产品

硝酸硫胺制备

维生素B1自然存在于米糠、麸皮、瘦肉、花生米等食物中，纯品通常由化学合成制备。过量的盐酸乙脒在碱性（甲醇和甲醇钠）介质中与α-二甲氧基-β-甲氧基丙腈缩合为3，6-二甲基-1，2-二氢-2，4，5，7-四氮萘，然后在98-100℃下水解，再在碱性条件下开环生成2-甲基-4-氨基-5-氨甲基嘧啶；接着与二硫化碳和氨水作用，然后与乙酸-γ-氯代-γ-乙酰丙酯缩合，再在盐酸中、75-78℃下水解和环合成硫代硫胺盐酸盐，最后用氨水中和、过氧化氢氧化、盐酸酸化得硫胺盐酸盐。

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硝酸硫胺海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

硝酸硫胺文献

Stability of hydrophilic vitamins mixtures in the presence of electrolytes and trace elements for parenteral nutrition: a nuclear magnetic resonance spectroscopy investigation.

J. Pharm. Biomed. Anal. 107 , 7-10, (2015)

In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the ...

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硝酸硫胺

硝酸硫胺用途

硝酸硫胺名称

硝酸硫胺生物活性

硝酸硫胺物理化学性质

硝酸硫胺MSDS

详细MSDS(安全技术说明书)

硝酸硫胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硝酸硫胺安全信息

硝酸硫胺合成路线

详细合成路线

硝酸硫胺上下游产品

硝酸硫胺上游产品

硝酸硫胺下游产品

硝酸硫胺制备

硝酸硫胺海关

硝酸硫胺文献

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