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硝酸硫胺

硝酸硫胺用途

Thiamine nitrate 是必不可少的维生素,能增强正常的神经元活性。
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硝酸硫胺名称

[ CAS 号 ]:
532-43-4

[ 中文名 ]:
硝酸硫胺

[ 英文名 ]:
Thiamine nitrate

[中文别名 ]:

[英文别名 ]:

硝酸硫胺生物活性

[ 描述 ]:

Thiamine nitrate 是必不可少的维生素,能增强正常的神经元活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 代谢疾病

[体外研究]

与WT小鼠(0.796±0.259μM)相比,喂食常规饮食的纯合KO和KI小鼠血液中的硫胺素水平分别在7周时降低至0.058±0.051和0.126±0.092μM。当WT和纯合KO和KI小鼠喂食硫胺素限制饮食(硫胺素:0.60 mg/100 g食物)时,血清硫胺素浓度在第5天和第14天分别显着降低至0.010±0.009和0.010±0.006μM, WT小鼠(0.609±0.288μM)。喂食常规饮食的WT小鼠脑匀浆中的硫胺素浓度为3.81±2.18nmol/g湿重,KO和KI的浓度分别为1.33±0.96和2.16±1.55nmol/g湿重。值得注意的是,在喂食硫胺素限制饮食(硫胺素:0.60 mg/100 g食品)5天(0.95±0.72 nmol/g湿重)和14天(1.11±0.24)的KO和KI小鼠中,脑匀浆中的硫胺素浓度稳定下降。在呈现疾病表型的小鼠之前,分别与WT(3.65±1.02nmol/g湿重)比较nmol/g湿重[2]。

[体内研究]

喂食常规饮食(硫胺素:1.71mg/100g)的WT,纯合和杂合KO和KI小鼠存活超过6个月而没有任何疾病表型。喂食硫胺素限制饮食的纯合KO和KI小鼠(硫胺素:0.60mg/100g食物)显示麻痹,体重减轻和不动,并且分别在12和30天内死亡。类似地,喂食硫胺限制饮食的纯合KO和KI小鼠分别在14天和18天内死亡,其中硫胺素(硫胺素:0.27mg/100g食物)的百分比甚至更低。然而,喂食硫胺限制饮食的WT和杂合KO和KI小鼠(硫胺素:0.60mg或0.27mg/100g食物)存活超过6个月而没有任何疾病表型[2]。

[动物实验]

Slc19a3 E314Q KI小鼠常规维持常规饮食,其具有1.71mg / 100g食物的硫胺素浓度(盐酸硫胺素,MW = 337.3)。根据“实验室啮齿动物的纯化日粮”制备两种硫胺素限制食品,其中硫胺素浓度为0.60 mg / 100 g食品(35%常规食品硫胺素)或0.27 mg / 100 g食品(16%硫胺素)传统食品)。含有高硫胺素的食物也是由AIN-93M制备的,其中硫胺素浓度是CE-2的5倍(硫胺素:8.50mg / 100g食物)[2]。

[参考文献]

[1]. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32.

[2]. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

硝酸硫胺物理化学性质

[ 熔点 ]:
196-200°C

[ 分子式 ]:
C12H17N5O4S

[ 分子量 ]:
327.359

[ 精确质量 ]:
327.100128

[ PSA ]:
173.03000

[ LogP ]:
1.47300

[ 外观性状 ]:
白色晶体粉末

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

硝酸硫胺MSDS

硝酸硫胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI7400000
CHEMICAL NAME :
Thiamine, nitrate
CAS REGISTRY NUMBER :
532-43-4
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C12-H17-N4-O-S.N-O3
MOLECULAR WEIGHT :
327.40
WISWESSER LINE NOTATION :
T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
113 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
387 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
84 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,153,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80545 No. of Facilities: 177 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 15363 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80545 No. of Facilities: 1106 (estimated) No. of Industries: 8 No. of Occupations: 36 No. of Employees: 39898 (estimated) No. of Female Employees: 18813 (estimated)
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硝酸硫胺安全信息

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
XI7400000

[ 海关编码 ]:
2934100090

硝酸硫胺合成路线

硝酸硫胺上下游产品

硝酸硫胺上游产品

硝酸硫胺下游产品

硝酸硫胺制备

维生素B1自然存在于米糠、麸皮、瘦肉、花生米等食物中,纯品通常由化学合成制备。过量的盐酸乙脒在碱性(甲醇和甲醇钠)介质中与α-二甲氧基-β-甲氧基丙腈缩合为3,6-二甲基-1,2-二氢-2,4,5,7-四氮萘,然后在98-100℃下水解,再在碱性条件下开环生成2-甲基-4-氨基-5-氨甲基嘧啶;接着与二硫化碳和氨水作用,然后与乙酸-γ-氯代-γ-乙酰丙酯缩合,再在盐酸中、75-78℃下水解和环合成硫代硫胺盐酸盐,最后用氨水中和、过氧化氢氧化、盐酸酸化得硫胺盐酸盐。

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硝酸硫胺海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

硝酸硫胺文献

Stability of hydrophilic vitamins mixtures in the presence of electrolytes and trace elements for parenteral nutrition: a nuclear magnetic resonance spectroscopy investigation.

J. Pharm. Biomed. Anal. 107 , 7-10, (2015)

In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the ...


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产品详情:维生素B1硝酸盐/硝酸硫铵/硝酸VB1/532-43-4


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