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细胞松驰素 H

细胞松驰素 H用途

细胞凝集素H是从真菌Phomopsis sp.中分离得到的天然产物。细胞凝集素H抑制细胞生长并诱导细胞凋亡。细胞松弛素H具有抗血管生成活性。细胞松弛素H是一种抗生素,具有抗菌活性[1][2][3]。

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细胞松驰素 H名称

[ CAS 号 ]:
53760-19-3

[ 中文名 ]:
细胞松弛素H

[ 英文名 ]:
Cytochalasin H

[中文别名 ]:

细胞松驰素 H

[英文别名 ]:

<11>Cytochalasin
paspalin
19-triene-1-one
cytochalasin U
paspalinpi
Paspalin P1
cytochalasinhfromphomopsissp.
kodocytochalasin-1

细胞松驰素 H生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> Bcl-2家族

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

信号通路 >> 抗感染 >> 细菌

[体外研究]

细胞松弛素H(24-72小时)抑制 A549细胞的增殖,IC50值为 159.5µM[1]细胞松弛素H(0-50µM；48小时)在 A549细胞中诱导细胞凋亡,使细胞周期停滞在 G2/M期,并影响细胞凋亡相关蛋白的表达[1] 细胞松弛素H(1-512μg/mL)对多学科研究肠道致病菌、革兰氏阳性菌和金黄色葡萄球菌具有抗菌活性[3] 细胞凋亡分析[1]细胞系：A549细胞浓度：0、6.25、12.5、25和50µM培养时间：48小时结果：以剂量依赖性方式诱导A549细胞凋亡。细胞周期分析[1]细胞系：A549细胞浓度：0、6.25、12.5、25和50µM培养时间：48小时结果：细胞周期停滞在G2/M期和亚G1期峰值。Western Blot分析[1]细胞系：A549细胞浓度：0、6.25、12.5、25和50µM孵育时间：48小时结果：增加Bax、P53和裂解的胱天蛋白酶3的蛋白表达水平,降低Bcl-xL、Bcl-2和全长胱天蛋白酶-3的蛋白表达量。

[体内研究]

细胞松弛素H(2.5 mg/kg；腹腔注射)可以延迟余额/cnu/nu小鼠中 A549异种移植肿瘤的生长[2] 动物模型：雄性Balb/cnu/nu小鼠A549异种移植物[2]剂量：2.5 mg/kg给药：腹腔注射；3次注射/周,持续80天结果：体内肿瘤生长减弱。

[参考文献]

[1]. Ma Y, et, al. Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells. Oncol Rep. 2018 Jun;39(6):2899-2905.

[2]. Yi JM, et, al. In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H. Biol Pharm Bull. 2015;38(6):909-12.

[3]. Jouda JB, et, al. Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement Altern Med. 2016 Nov 14;16(1):462.

细胞松驰素 H物理化学性质

[ 密度 ]:
1.19g/cm3

[ 沸点 ]:
676.5ºC at 760mmHg

[ 熔点 ]:
252-258ºC

[ 分子式 ]:
C₃₀H₃₉NO₅

[ 分子量 ]:
493.63

[ 闪点 ]:
362.9ºC

[ 精确质量 ]:
493.28300

[ PSA ]:
95.86000

[ LogP ]:
4.06690

[ 折射率 ]:
1.591

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: 10 mg/mL, clear, colorless

细胞松驰素 HMSDS

详细MSDS(安全技术说明书)

细胞松驰素 H毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5306000

CHEMICAL NAME :: (11)Cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10- phenyl-, (7S,13E,16S,18S,19E,21R)-

CAS REGISTRY NUMBER :: 53760-19-3

LAST UPDATED :: 199107

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C30-H39-N-O5

MOLECULAR WEIGHT :: 493.70

WISWESSER LINE NOTATION :: T56-11- 1A R AXVM GY JU PUTJ D1R& F1 GU1 HQ M1 OQ O1 ROV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 12500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2341 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 ug/L

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,430,1978

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细胞松驰素 H安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330-H361

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28-63

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 3462 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
HA5306000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

细胞松驰素 H合成路线

详细合成路线

细胞松驰素 H文献

A new fungal isolate from Paspalum scrobiculatum, Linn. with new biologically active metabolites.

Acta Microbiol. Acad. Sci. Hung. 22 , 253, (1975)

A new fungal isolate from the host plant Paspalum scrobiculatum Linn., is reported. It is characterized and designated as a separate species Phomopsis paspali (n. sp.), not only for the different morp...

Effects of cytochalasin H on chick embryo explants cultured in vitro.

Toxicology 33(3-4) , 323-30, (1984)

Effects of the mould metabolite, cytochalasin H (CH) were studied in chick embryos explanted at stages 4, 5 and 8 and cultured in vitro. Morphological and histological observations revealed that the m...

Inhibitory effect of cytochalasin H on cell reaggregation of the fresh water sponge, Ephydatia meyeni Carter.

Exp. Cell Biol. 50(3) , 155-61, (1982)

Cytochalasin H (CH) has been shown to inhibit the reaggregation of dissociated cells of a fresh water sponge. The effect is dose-dependent and reversible. Even after 24 h of CH treatment, the cells sh...

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