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β-巯基乙胺

β-巯基乙胺用途

Cysteamine为抗氧化剂,可作用于肾病型胱胺酸症。

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β-巯基乙胺名称

[ CAS 号 ]:
60-23-1

[ 中文名 ]:
β-巯基乙胺

[ 英文名 ]:
2-Aminoethanethiol

[中文别名 ]:

[英文别名 ]:

b-MEA
Ethanethiol, 2-amino-
2-Aminoethanethiol
Thioethanolamine
β-aminoethylthiol
β-mercaptoethylamine
Mercamine
MEA
mercaptoethylamine
mercaptamine

β-巯基乙胺生物活性

[ 描述 ]:

Cysteamine为抗氧化剂,可作用于肾病型胱胺酸症。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

[2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

[相关活性小分子]

β-巯基乙胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
133.6±23.0 °C at 760 mmHg

[ 熔点 ]:
95°C

[ 分子式 ]:
C₂H₇NS

[ 分子量 ]:
77.149

[ 闪点 ]:
34.6±22.6 °C

[ 精确质量 ]:
77.029922

[ PSA ]:
64.82000

[ LogP ]:
0.03

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
8.4±0.2 mmHg at 25°C

[ 折射率 ]:
1.486

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable, but may be air-sensitive. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：可溶；可溶于：醇；极微溶：乙醚

β-巯基乙胺MSDS

详细MSDS(安全技术说明书)

β-巯基乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ0175000

CHEMICAL NAME :: Ethanethiol, 2-amino-

CAS REGISTRY NUMBER :: 60-23-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C2-H7-N-S

MOLECULAR WEIGHT :: 77.16

WISWESSER LINE NOTATION :: Z2SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 232 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 42 gm/kg

SEX/DURATION :: female 70 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,351,1979

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β-巯基乙胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
3259

[ WGK德国 ]:
3

[ RTECS号 ]:
KJ0175000

β-巯基乙胺合成路线

详细合成路线

β-巯基乙胺上下游产品

β-巯基乙胺上游产品

β-巯基乙胺下游产品

β-巯基乙胺制备

由乙醇胺与溴化氢加成得β-溴化乙胺，再于硫酸存在下与二硫化碳环合，最后水解而得。此法反应容易控制，对设备要求不高，适于工业采用。另外，由环乙胺与硫化氢加成，亦可制得。

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β-巯基乙胺文献

Mediated Electron Transfer at Vertically Aligned Single-Walled Carbon Nanotube Electrodes During Detection of DNA Hybridization.

Nanoscale Res. Lett. 10 , 978, (2015)

Vertically aligned single-walled carbon nanotube (VASWCNT) assemblies are generated on cysteamine and 2-mercaptoethanol (2-ME)-functionalized gold surfaces through amide bond formation between carboxy...

A nanoplasmonic biosensor for label-free multiplex detection of cancer biomarkers.

Biosens. Bioelectron. 74 , 341-6, (2015)

The development of highly sensitive, selective and multiplex sensors has become an important challenge for disease diagnosis. In this study, we describe a multiplex biosensor for the detection of canc...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

更多文献

β-巯基乙胺

β-巯基乙胺用途

β-巯基乙胺名称

β-巯基乙胺生物活性

β-巯基乙胺物理化学性质

β-巯基乙胺MSDS

详细MSDS(安全技术说明书)

β-巯基乙胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

β-巯基乙胺安全信息

β-巯基乙胺合成路线

详细合成路线

β-巯基乙胺上下游产品

β-巯基乙胺上游产品

β-巯基乙胺下游产品

β-巯基乙胺制备

β-巯基乙胺文献

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