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胸腺肽α1

胸腺肽α1用途

Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物,能够提高 Thl 的免疫应答。

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胸腺肽α1名称

[ CAS 号 ]:
62304-98-7

[ 中文名 ]:
胸腺28肽

[ 英文名 ]:
Thymosin α1

[中文别名 ]:

[英文别名 ]:

ZADAXIN
THYMOSIN ALPHA1 BOVINE
Thymosin alpha1
thymalfasin
AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Thymosin a1 Acetate
MFCD00076889
Thymosin Alpha1 Acetate
THYMOSIN A1
THYMOSIN A1 BOVINE

胸腺肽α1生物活性

[ 描述 ]:

Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物,能够提高 Thl 的免疫应答。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

多肽产品

[体外研究]

Thymalfasin已被证明在免疫功能障碍的多个实验模型中有效,主要是感染性疾病,如肝炎(土拨鼠)和流感(小鼠),以及癌症,如黑色素瘤(小鼠)和结肠直肠癌(大鼠),其中thymalfasin已显示抗肿瘤效果[2]。

[体内研究]

[参考文献]

[1]. Lao X et al. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects. Apoptosis. 2015 Oct;20(10):1307-20.

[2]. Sjogren MH et al. Thymalfasin: an immune system enhancer for the treatment of liver disease. J Gastroenterol Hepatol. 2004 Dec;19(12):S69-72.

[相关活性小分子]

胸腺肽α1物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
2899.7±65.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂₉H₂₁₅N₃₃O₅₅

[ 分子量 ]:
3108.275

[ 闪点 ]:
1707.5±34.3 °C

[ 精确质量 ]:
3106.504150

[ PSA ]:
1456.35000

[ LogP ]:
-9.87

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.563

[ 储存条件 ]:
−20°C

胸腺肽α1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

胸腺肽α1文献

Production of Nα-acetylated thymosin α1 in Escherichia coli.

Microb. Cell Fact. 10 , 26, (2011)

Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can o...

Thymosin alpha 1: biological activities, applications and genetic engineering production.

Peptides 31 , 2151-2158, (2010)

Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate...

Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.

Front. Biosci. 17 , 3004-3013, (2011)

Tregs are involved in immune disorder during sepsis; they can lead to a Th2 immune reaction. Their inhibitory effects can help alleviate inflammatory injury, but may also cause secondary immune inhibi...

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