< 生产厂家价格 >

维生素B6

维生素B6用途

Pyridoxine 是一种吡啶衍生物。Pyridoxine 作用于阿尔茨海默病细胞模型,通过 Nrf-2/HO-1 途径发挥抗氧化作用。

点击显示

维生素B6名称

[ CAS 号 ]:
65-23-6

[ 中文名 ]:
吡多素

[ 英文名 ]:
Pyridoxine

[中文别名 ]:

[英文别名 ]:

4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
3-Hydroxy-4,5-dimethylol-a-picoline
Pyridoxine
EINECS 200-386-2
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
Pirivitol
3-hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Pyridoxol

维生素B6生物活性

[ 描述 ]:

Pyridoxine 是一种吡啶衍生物。Pyridoxine 作用于阿尔茨海默病细胞模型,通过 Nrf-2/HO-1 途径发挥抗氧化作用。

[ 相关类别 ]:

信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

吡哆醇对AD具有保护作用,减弱ROS水平,降低细胞质Nrf2的表达,并上调全细胞HO-1表达[1]。

[参考文献]

[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

[相关活性小分子]

维生素B6物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
491.9±40.0 °C at 760 mmHg

[ 熔点 ]:
159-162ºC

[ 分子式 ]:
C₈H₁₁NO₃

[ 分子量 ]:
169.178

[ 闪点 ]:
251.3±27.3 °C

[ 精确质量 ]:
169.073898

[ PSA ]:
73.58000

[ LogP ]:
-1.10

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.621

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
H2O: 0.1 g/mL at 20 °C, clear, colorless

维生素B6MSDS

维生素B6毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1300000

CHEMICAL NAME :: Pyridoxol

CAS REGISTRY NUMBER :: 65-23-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H11-N-O3

MOLECULAR WEIGHT :: 169.20

WISWESSER LINE NOTATION :: T6NJ B1 CQ D1Q E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2100 mg/kg/30D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis Behavioral - ataxia

REFERENCE :: NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 35,1466,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4800 mg/kg/17W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,445,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 139 mg/kg/5Y-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 311,986,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5143 mg/kg/17W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,445,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,116,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,116,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 657 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 44,147,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 966 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 40,371,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 545 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,683,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4524 No. of Facilities: 630 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 14045 (estimated) No. of Female Employees: 5607 (estimated)

点击显示

维生素B6安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UV1350000

[ 海关编码 ]:
29362500

维生素B6合成路线

维生素B6上下游产品

维生素B6上游产品

维生素B6下游产品

维生素B6制备

【方法一】
存在于稻谷壳、甘蔗、酵母、麦芽等中。可从多种途径合成。

点击显示

维生素B6海关

[ 海关编码 ]: 2936250000

[ 申报要素 ]: 品名, 成分含量, 用途, 包装, 是否吸附于载体(如硅胶)

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%

维生素B6文献

Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.

Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014)

We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

更多文献

维生素B6

维生素B6用途

维生素B6名称

维生素B6生物活性

维生素B6物理化学性质

维生素B6MSDS

详细MSDS(安全技术说明书)

维生素B6毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

维生素B6安全信息

维生素B6合成路线

详细合成路线

维生素B6上下游产品

维生素B6上游产品

维生素B6下游产品

维生素B6制备

维生素B6海关

维生素B6文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物