氯化乙酰胆碱；乙酰氯化胆碱

氯化乙酰胆碱；乙酰氯化胆碱用途

Acetylcholine是神经递质,能诱导钙离子通道开放。

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氯化乙酰胆碱；乙酰氯化胆碱作用

氯化乙酰胆碱为M、N胆碱受体激动药，选择性低，作用广泛、短暂。小剂量即可明显兴奋M胆碱受体，剂量稍大时，也激动N胆碱受体。M样作用表现为血管扩张、心率减慢、心肌收缩力下降、血压降低，胃肠道、支气管、泌尿道和胆道平滑肌兴奋，瞳孔括约肌和睫状肌收缩，泪腺、汗腺、消化腺和支气管腺体分泌增加等。这些M样作用全部可被阿托品所取消。N样作用包括NM和NN受体兴奋所引起的反应。NN受体兴奋后可见全部植物神经节和肾上腺髓质嗜铬细胞兴奋，前者表现为交感和副交感神经同时兴奋，在效应器上呈现拮抗作用，其最终效应常取决于哪一类神经占优势。后者则可促进肾上腺素释放。NM受体兴奋主要表现为骨骼肌收缩，此作用可被筒毒碱所阻断。

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氯化乙酰胆碱；乙酰氯化胆碱名称

[ CAS 号 ]:
60-31-1

[ 中文名 ]:
氯化乙酰胆碱

[ 英文名 ]:
Acetylcholine chloride

[中文别名 ]:

[英文别名 ]:

Acetylcholine chloride
2-Acetoxy-N,N,N-trimethylethanaminium chloride
Ovisot
Acecoline
EINECS 200-468-8
MFCD00011698
Arterocoline
2-(acetyloxy)-N,N,N-trimethylethanaminium chloride
2-(Acetyloxy)-N,N,N-trimethylethanaminiumchlorid
Acetylcholinium chloride

氯化乙酰胆碱；乙酰氯化胆碱生物活性

[ 描述 ]:

Acetylcholine是神经递质,能诱导钙离子通道开放。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 跨膜转运 >> 钙通道

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. Pepeu, G. and P. Blandina, The acetylcholine, GABA, glutamate triangle in the rat forebrain. J Physiol Paris, 1998. 92(5-6): p. 351-5.

[2]. Israel, M. and Y. Dunant, Acetylcholine release and the cholinergic genomic locus. Mol Neurobiol, 1998. 16(1): p. 1-20.

[3]. Lei, X., et al., Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res, 2008. 300(7): p. 335-41.

[相关活性小分子]

氯化乙酰胆碱；乙酰氯化胆碱物理化学性质

[ 熔点 ]:
146-150 °C(lit.)

[ 分子式 ]:
C₇H₁₆ClNO₂

[ 分子量 ]:
181.660

[ 精确质量 ]:
181.086960

[ PSA ]:
26.30000

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.

[ 水溶解性 ]:
可溶 IN COLD WATER

氯化乙酰胆碱；乙酰氯化胆碱MSDS

详细MSDS(安全技术说明书)

氯化乙酰胆碱；乙酰氯化胆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ9800000

CHEMICAL NAME :: Choline acetate (ester), chloride

CAS REGISTRY NUMBER :: 60-31-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H16-N-O2.Cl

MOLECULAR WEIGHT :: 181.69

WISWESSER LINE NOTATION :: 1VO2K1&1&1 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15300 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 20(4),32,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,541,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 7700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 170,461,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - stiffness Cardiac - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 166,437,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 164,346,1932 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3203 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2698 (estimated) No. of Female Employees: 1846 (estimated)

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氯化乙酰胆碱；乙酰氯化胆碱安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
FZ9800000

[ 海关编码 ]:
29379000

氯化乙酰胆碱；乙酰氯化胆碱合成路线

详细合成路线

氯化乙酰胆碱；乙酰氯化胆碱上下游产品

氯化乙酰胆碱；乙酰氯化胆碱上游产品

氯化乙酰胆碱；乙酰氯化胆碱下游产品

氯化乙酰胆碱；乙酰氯化胆碱制备

以氯乙醇和三甲胺水溶液为起始原料反应，再经乙酸酐酰化，最后精制而成。

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氯化乙酰胆碱；乙酰氯化胆碱海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

氯化乙酰胆碱；乙酰氯化胆碱文献

Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule.

Alcohol. Clin. Exp. Res. 38(11) , 2722-30, (2014)

Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

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氯化乙酰胆碱；乙酰氯化胆碱

氯化乙酰胆碱；乙酰氯化胆碱用途

氯化乙酰胆碱；乙酰氯化胆碱作用

氯化乙酰胆碱；乙酰氯化胆碱名称

氯化乙酰胆碱；乙酰氯化胆碱生物活性

氯化乙酰胆碱；乙酰氯化胆碱物理化学性质

氯化乙酰胆碱；乙酰氯化胆碱MSDS

详细MSDS(安全技术说明书)

氯化乙酰胆碱；乙酰氯化胆碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

氯化乙酰胆碱；乙酰氯化胆碱安全信息

氯化乙酰胆碱；乙酰氯化胆碱合成路线

详细合成路线

氯化乙酰胆碱；乙酰氯化胆碱上下游产品

氯化乙酰胆碱；乙酰氯化胆碱上游产品

氯化乙酰胆碱；乙酰氯化胆碱下游产品

氯化乙酰胆碱；乙酰氯化胆碱制备

氯化乙酰胆碱；乙酰氯化胆碱海关

氯化乙酰胆碱；乙酰氯化胆碱文献

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氯化乙酰胆碱； 乙酰氯化胆碱

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氯化乙酰胆碱； 乙酰氯化胆碱作用

氯化乙酰胆碱； 乙酰氯化胆碱名称

氯化乙酰胆碱； 乙酰氯化胆碱生物活性

氯化乙酰胆碱； 乙酰氯化胆碱物理化学性质

氯化乙酰胆碱； 乙酰氯化胆碱MSDS

详细MSDS(安全技术说明书)

氯化乙酰胆碱； 乙酰氯化胆碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

氯化乙酰胆碱； 乙酰氯化胆碱安全信息

氯化乙酰胆碱； 乙酰氯化胆碱合成路线

详细合成路线

氯化乙酰胆碱； 乙酰氯化胆碱上下游产品

氯化乙酰胆碱； 乙酰氯化胆碱上游产品

氯化乙酰胆碱； 乙酰氯化胆碱下游产品

氯化乙酰胆碱； 乙酰氯化胆碱制备

氯化乙酰胆碱； 乙酰氯化胆碱海关

氯化乙酰胆碱； 乙酰氯化胆碱文献

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氯化乙酰胆碱；乙酰氯化胆碱

氯化乙酰胆碱；乙酰氯化胆碱用途

氯化乙酰胆碱；乙酰氯化胆碱作用

氯化乙酰胆碱；乙酰氯化胆碱名称

氯化乙酰胆碱；乙酰氯化胆碱生物活性

氯化乙酰胆碱；乙酰氯化胆碱物理化学性质

氯化乙酰胆碱；乙酰氯化胆碱MSDS

氯化乙酰胆碱；乙酰氯化胆碱毒性和生态

氯化乙酰胆碱；乙酰氯化胆碱安全信息

氯化乙酰胆碱；乙酰氯化胆碱合成路线

氯化乙酰胆碱；乙酰氯化胆碱上下游产品

氯化乙酰胆碱；乙酰氯化胆碱上游产品

氯化乙酰胆碱；乙酰氯化胆碱下游产品

氯化乙酰胆碱；乙酰氯化胆碱制备

氯化乙酰胆碱；乙酰氯化胆碱海关

氯化乙酰胆碱；乙酰氯化胆碱文献