醋酸氟轻松
醋酸氟轻松用途
用于过敏性皮炎、接触性皮炎、脂溢性皮炎及湿疹等。
醋酸氟轻松名称
[ CAS 号 ]:
67-73-2
[ 中文名 ]:
醋酸氟轻松
[ 英文名 ]:
Fluocinolone Acetonide
[中文别名 ]:
[英文别名 ]:
- EINECS 200-668-5
- MFCD00010525
- Fluocinolone Acetonide
- Fluocinolone (Acetonide)
醋酸氟轻松生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
醋酸氟轻松物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
578.5±50.0 °C at 760 mmHg
[ 熔点 ]:
267-269 °C(lit.)
[ 分子式 ]:
C24H30F2O6
[ 分子量 ]:
452.488
[ 闪点 ]:
303.7±30.1 °C
[ 精确质量 ]:
452.201050
[ PSA ]:
93.06000
[ LogP ]:
2.24
[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C
[ 折射率 ]:
1.577
[ 储存条件 ]:
Refrigerator
醋酸氟轻松MSDS
醋酸氟轻松毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU3830000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,12-dihydroxy-16,17-((1-methylethylide ne) bis(oxy))-, (6-alpha,11-beta,16-alpha)-
- CAS REGISTRY NUMBER :
- 67-73-2
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C24-H30-F2-O6
- MOLECULAR WEIGHT :
- 452.54
- WISWESSER LINE NOTATION :
- T F5 E5 B666 GO IO RV AHTTTT&J A BF CQ E FVIQ H H OF -A&BHO -B&ACEF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 108 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 103 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >3170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1750 ug/kg/35D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1200 ug/kg
- SEX/DURATION :
- female 8-31 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1625 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 620 ug/L
- REFERENCE :
- AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83287 No. of Facilities: 100 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1551 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83287 No. of Facilities: 72 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4106 (estimated) No. of Female Employees: 3249 (estimated)
醋酸氟轻松安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R40
[ 安全声明 (欧洲) ]:
S26-S36-S22
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
TU3830000
[ 海关编码 ]:
2937210000
醋酸氟轻松合成路线
醋酸氟轻松上下游产品
醋酸氟轻松上游产品
醋酸氟轻松下游产品
醋酸氟轻松海关
[ 海关编码 ]: 2937210000
醋酸氟轻松文献
J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrinsBioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.Bioorg. Med. Chem. 18 , 2225-31, (2010)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one pa...
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公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
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联系人:徐经理
产品详情:氟轻松
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
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联系人:赖经理
产品详情:Fluocinolone acetonide (Flucort-N)
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥439.0/100mg
¥489.0/1g
¥589.0/200mg
¥需询单/1g
联系人:李先生
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥493.9/1g
¥199.9/250mg
¥1699.9/5g
¥6299.9/25g
联系人:阿拉丁
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥441.0/100mg
¥需询单/1ml
¥588.0/200mg
联系人:夏言
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相关化合物
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