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醋酸氟轻松

醋酸氟轻松用途

Fluocinonide (Vanos)是糖皮质激素类固醇,具有抗炎活性,可作用于皮肤疾病。

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醋酸氟轻松名称

[ CAS 号 ]:
356-12-7

[ 中文名 ]:
醋酸氟轻松

[ 英文名 ]:
FLUOCINONIDE

[中文别名 ]:

[英文别名 ]:

Ethylacetat
FLUOCINONIDE
oethyl acetate
Topsym

醋酸氟轻松生物活性

[ 描述 ]:

Fluocinonide (Vanos)是糖皮质激素类固醇,具有抗炎活性,可作用于皮肤疾病。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. http://en.wikipedia.org/wiki/Fluocinonide

[相关活性小分子]

醋酸氟轻松物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
591.1±50.0 °C at 760 mmHg

[ 熔点 ]:
309ºC

[ 分子式 ]:
C₂₆H₃₂F₂O₇

[ 分子量 ]:
494.525

[ 闪点 ]:
311.3±30.1 °C

[ 精确质量 ]:
494.211609

[ PSA ]:
99.13000

[ LogP ]:
3.36

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±3.8 mmHg at 25°C

[ 折射率 ]:
1.560

[ 储存条件 ]:
室温

醋酸氟轻松MSDS

详细MSDS(安全技术说明书)

醋酸氟轻松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3831000

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 6-alpha, 9-difluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 17-acetal with acetone, 21-acetate

CAS REGISTRY NUMBER :: 356-12-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C26-H32-F2-O7

MOLECULAR WEIGHT :: 494.58

WISWESSER LINE NOTATION :: T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1 FV1OV1 H1 H1 OF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 720 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >3170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3750 ug/kg/30D-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

REFERENCE :: BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 94,1,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6123 No. of Facilities: 52 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 10431 (estimated) No. of Female Employees: 9606 (estimated)

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醋酸氟轻松安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H361

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P280

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
22-25-28-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TU3831000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2937210000

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醋酸氟轻松上游产品

醋酸氟轻松下游产品

醋酸氟轻松海关

[ 海关编码 ]: 2937210000

醋酸氟轻松文献

Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis.

Journal. of. Drugs in. Dermatology. 10(2) , 171-6, (2011)

To determine the effect a novel formulation of fluocinonide cream on skin barrier function in subjects with atopic dermatitis.The authors performed an open-label, investigator-blinded, side-by-side, c...

Urticarial hypersensitivity reaction caused by temozolomide.

Journal. of. Drugs in. Dermatology. 9(9) , 1142-4, (2010)

Temozolomide is an oral alkylating agent approved for the treatment of glioblastoma and anaplastic astrocytoma, and is currently under clinical investigation for the treatment of brain metastases from...

In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle.

Journal. of. Drugs in. Dermatology. 7(1) , 28-32, (2008)

Prolonged topical corticosteroid use is often associated with atrophic skin changes. This trial compared signs of skin atrophy related to 3 super-high-potency corticosteroids: fluocinonide 0.1% cream,...

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