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ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET

用途

Substance P, Free Acid 是 substance P 的类似物,但是不具有 substance P 的生物活性。

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名称

[ CAS 号 ]:
71977-09-8

[ 中文名 ]:
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET

[ 英文名 ]:
Substance P (free acid)

[英文别名 ]:

H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH
RPKPQQFFGLM
H-RPKPQQFFGLM-OH
RPKPQQFFGLM-OH
[Met-OH11] substance P
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
Substance P, free acid

生物活性

[ 描述 ]:

Substance P, Free Acid 是 substance P 的类似物,但是不具有 substance P 的生物活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

多肽产品

研究领域 >> 其他

[参考文献]

[1]. Patel AB, et al. Substance P (free acid) adopts different conformation than native peptide in DMSO, water and DPPC bilayers. J Biomol Struct Dyn. 2001 Aug;19(1):129-38.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.41 g/cm3

[ 分子式 ]:
C₆₃H₉₇N₁₇O₁₄S

[ 分子量 ]:
1348.61000

[ 精确质量 ]:
1347.71000

[ PSA ]:
536.14000

[ LogP ]:
4.09310

[ 储存条件 ]:
2-8℃

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

合成路线

详细合成路线

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文献

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Synthesis of peptides by the solid-phase method. 7. Substance P and analogues.

J. Med. Chem. 25 , 64, (1982)

Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the comp...

Biological activity of substance P methyl ester.

Mol. Pharmacol. 20 , 457, (1981)

更多文献