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三溴乙醇

三溴乙醇用途

Tribromoethyl alcohol 是一种羟基保护剂, 用作麻醉剂。

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三溴乙醇名称

[ CAS 号 ]:
75-80-9

[ 中文名 ]:
三溴乙醇

[ 英文名 ]:
2,2,2-Tribromoethanol

[中文别名 ]:

三溴乙醇 (阿佛丁)

[英文别名 ]:

MFCD00004671
UNII:149JI83A44
Tribromoethanol
Ethanol, 2,2,2-tribromo-
EINECS 200-903-1
2,2,2-Tribromoethan-1-ol
Tribromoethanol, 2,2,2-
Tribromoethyl alcohol
2,2,2-Tribromoethanol

三溴乙醇生物活性

[ 描述 ]:

Tribromoethyl alcohol 是一种羟基保护剂, 用作麻醉剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Hill WA, et al. Repeated administration of tribromoethanol in C57BL/6NHsd mice. J Am Assoc Lab Anim Sci. 2013 Mar;52(2):176-179.

[相关活性小分子]

三溴乙醇物理化学性质

[ 密度 ]:
2.9±0.1 g/cm3

[ 沸点 ]:
199.0±0.0 °C at 760 mmHg

[ 熔点 ]:
73-79 °C(lit.)

[ 分子式 ]:
C₂H₃Br₃O

[ 分子量 ]:
282.757

[ 闪点 ]:
99.7±25.9 °C

[ 精确质量 ]:
279.773376

[ PSA ]:
20.23000

[ LogP ]:
2.30

[ 外观性状 ]:
黄褐色结晶粉末

[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C

[ 折射率 ]:
1.651

[ 储存条件 ]:
通风低温干燥

三溴乙醇MSDS

详细MSDS(安全技术说明书)

三溴乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM3675000

CHEMICAL NAME :: Ethanol, 2,2,2-tribromo-

CAS REGISTRY NUMBER :: 75-80-9

BEILSTEIN REFERENCE NO. :: 1733249

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C2-H3-Br3-O

MOLECULAR WEIGHT :: 282.78

WISWESSER LINE NOTATION :: Q1XEEE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,183,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 182,348,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 56,920,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 132,214,1928

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity)

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 132,214,1928

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 55,1,1935

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三溴乙醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KM3675000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
29159080

三溴乙醇合成路线

详细合成路线

三溴乙醇上下游产品

三溴乙醇上游产品

三溴乙醇下游产品

三溴乙醇海关

[ 海关编码 ]: 29159080

三溴乙醇文献

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