氯美扎酮

氯美扎酮用途

用途用作弱安定药。具有镇静、安定和中枢性肌肉松驰作用。也可用于精神紧张恐惧、慢性疲劳、焦虑、激动，以及某些疾病引起的烦躁不眠等。因有肌肉松驰作用，配合镇痛药可用于背酸、颈硬、骨痛、脊椎及四肢酸痛和风湿关节痛等。
用途弱安定药，用于精神紧张恐惧、慢性疲劳、焦虑、激动以及某些疾病引起的烦躁不眠等
其他：震颤性麻痹、震颤、瘫痪、血管硬化及脑震荡出血等。

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氯美扎酮名称

[ CAS 号 ]:
80-77-3

[ 中文名 ]:
氯美扎酮

[ 英文名 ]:
chlormezanone

[中文别名 ]:

[英文别名 ]:

Suprotan
(±)-Chlormezanone
Transanate
UNII:GP568V9G19
Lobak
MFCD00143951
chlormezanone
Dichloromethazanone
UNII:C14WB33Y0S
UNII:4BU37OM8KL

氯美扎酮生物活性

[ 描述 ]:

Chlormezanone 与苯二氮卓类药物 (benzodiazepine) 类似。Chlormezanone 的作用与苯二氮卓类药物相似。Chlormezanone 用作抗焦虑药和肌肉松弛剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[ 靶点 ]

Benzodiazepine[1]

[体内研究]

氯米松在剂量水平上获得的对比结果能够在对侧伸肌中产生超过80％的抑郁[1]。

[动物实验]

猫[1]对脊髓猫的舌下颌，伸肌和髌骨反射研究各种药物（例如，氯米松300mg / kg ip）的作用。

[参考文献]

[1]. Sukehiro CHIBA, et al. EFFECTS OF NEW s-TRIAZOLOBENZODIAZEPINE (D-4OTA) AND OTHER CENTRAL MUSCLE RELAXANTS ON SPINAL AND SUPRASPINAL REFLEXES IN CATS. Japan. J. Pharmacol, 23, 83-96 (1973).

[相关活性小分子]

氯美扎酮物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
534.5±50.0 °C at 760 mmHg

[ 熔点 ]:
114ºC

[ 分子式 ]:
C₁₁H₁₂ClNO₃S

[ 分子量 ]:
273.736

[ 闪点 ]:
277.1±30.1 °C

[ 精确质量 ]:
273.022644

[ PSA ]:
62.83000

[ LogP ]:
0.86

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.580

[ 储存条件 ]:
Store at RT

氯美扎酮MSDS

详细MSDS(安全技术说明书)

氯美扎酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ1050000

CHEMICAL NAME :: 4H-1,3-Thiazin-4-one, 2-(p-chlorophenyl)tetrahydro-3-methyl-, 1,1,-dioxide

CAS REGISTRY NUMBER :: 80-77-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C11-H12-Cl-N-O3-S

MOLECULAR WEIGHT :: 273.75

WISWESSER LINE NOTATION :: T6VN DSWTJ B1 CR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes

REFERENCE :: HOCHE8 Hochudoku. (Nippon Hochudoku Gakkai, c/o Kyushu Daigaku Igakubu Hoigaku Kyoshitsu, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan) V.8- 1990- Volume(issue)/page/year: 9,168,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 157 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - ataxia Behavioral - coma

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,732,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Behavioral - coma Vascular - BP lowering not characterized in autonomic section

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 286,845,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 605 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 130,280,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,601,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 514 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 19,603,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 322 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,247,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3975 mg/kg/5D-C

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959

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氯美扎酮安全信息

[ 危害码 (欧洲) ]:
Xn

[ RTECS号 ]:
XJ1050000

氯美扎酮制备

由对氯苯甲醛经与甲胺溶液缩合、巯基丙酸环合、高锰酸钾溶液氧化而得。

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氯美扎酮

氯美扎酮用途

氯美扎酮名称

氯美扎酮生物活性

氯美扎酮物理化学性质

氯美扎酮MSDS

详细MSDS(安全技术说明书)

氯美扎酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

氯美扎酮安全信息

氯美扎酮制备

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