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甲磺酸双氢麦角碱

甲磺酸双氢麦角碱用途

Dihydroergotoxine mesylate是系列生物碱盐混合物,对GABAA受体高结合活性。

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甲磺酸双氢麦角碱名称

[ CAS 号 ]:
8067-24-1

[ 中文名 ]:
甲磺酸双氢麦角碱

[ 英文名 ]:
Dihydroergotoxine mesylate

[中文别名 ]:

[英文别名 ]:

Decril
circanol
Sponsin
Dihydroergotoxine mesylate
Dacoren
Trigot
Inorter
Lavendustin A
cck179
Dulcion

甲磺酸双氢麦角碱生物活性

[ 描述 ]:

Dihydroergotoxine mesylate是系列生物碱盐混合物,对GABAA受体高结合活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Tvrdeic A, et al. Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore. Eur J Pharmacol. 1991 Sep 4;202(1):109-11.

[2]. Tvrdeic A, et al. Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain. Eur J Pharmacol. 1992 Oct 6;221(1):139-43.

[3]. Tvrdeic A, et al. Effect of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors. Coll Antropol. 2003;27 Suppl 1:175-82.

[4]. Abdul M, et al. Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer. Acta Oncol. 2008;47(8):1546-50.

[相关活性小分子]

甲磺酸双氢麦角碱物理化学性质

[ 密度 ]:
1.34g/cm3

[ 沸点 ]:
899.5ºC at 760 mmHg

[ 分子式 ]:
C₁₂₃H₁₅₆N₂₀O₂₃S

[ 分子量 ]:
2314.74

[ 闪点 ]:
497.8ºC

[ PSA ]:
131.11000

[ LogP ]:
2.53850

[ 折射率 ]:
1.66

[ 储存条件 ]:
Store at RT

甲磺酸双氢麦角碱MSDS

详细MSDS(安全技术说明书)

甲磺酸双氢麦角碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE8800000

CHEMICAL NAME :: Ergotoxine, dihydro-, methanesulfonate

CAS REGISTRY NUMBER :: 8067-24-1

LAST UPDATED :: 199504

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 86 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10 mg/kg

SEX/DURATION :: female 12-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 50,317,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3183 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

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甲磺酸双氢麦角碱安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
60

[ 安全声明 (欧洲) ]:
53-36/37/39-45

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
KE8800000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

甲磺酸双氢麦角碱文献

Pharmacological treatments of cerebellar ataxia.

Cerebellum 3(2) , 107-11, (2004)

The confirmed pharmacological treatment of cerebellar ataxia is still lacking. In a recent preliminary trial, we showed that D-cycloserine, a partial NMDA allosteric agonist, may relieve the symptoms....

Cerebroprotective drugs shorten the hypoxia-induced onset of electrical silence in unanesthetized rats.

Pharmacol. Res. 42(3) , 261-8, (2000)

Pharmacological agents that delay the hypoxic arrest of neuronal electrical activity, as indicated by the suppression of electroencephalogram (EEG), have previously been thought to increase brain resi...

Identification and human pharmacokinetics of dihydroergotoxine metabolites in man: preliminary results.

Biopharm. Drug Dispos. 29(1) , 17-28, (2008)

Dihydroergotoxine is a mixture of semi-synthetic ergot alkaloids mainly used for age-related cognitive impairment. In this study, dihydroergotoxine (30 microM) was added to incubates of rat and bovine...

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