甲基泼尼松龙
甲基泼尼松龙用途
适用于风湿性关节炎、胶原病、过敏性疾病、眼科疾患、淋巴白血病、软组织炎症及溶血性贫血等。
甲基泼尼松龙名称
[ CAS 号 ]:
83-43-2
[ 中文名 ]:
6α-甲基泼尼松龙
[ 英文名 ]:
Methylprednisolone
[中文别名 ]:
[英文别名 ]:
- MFCD00010591
- EINECS 201-476-4
- Methylprednisolone
- 6alpha-methylprednisolone
甲基泼尼松龙生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
甲基泼尼松龙物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
571.8±50.0 °C at 760 mmHg
[ 熔点 ]:
228-237°C (dec.)
[ 分子式 ]:
C22H30O5
[ 分子量 ]:
374.471
[ 闪点 ]:
313.7±26.6 °C
[ 精确质量 ]:
374.209320
[ PSA ]:
94.83000
[ LogP ]:
1.99
[ 外观性状 ]:
白色至灰白色结晶粉末
[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C
[ 折射率 ]:
1.603
[ 储存条件 ]:
0-6°C
[ 水溶解性 ]:
chloroform/methanol (9:1): 50 mg/mL, clear, faintly yellow
甲基泼尼松龙MSDS
甲基泼尼松龙毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4146000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione, 6-alpha-methyl-11-beta-17,21-trihydroxy-
- CAS REGISTRY NUMBER :
- 83-43-2
- BEILSTEIN REFERENCE NO. :
- 2340300
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C22-H30-O5
- MOLECULAR WEIGHT :
- 374.52
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q FQ L1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 ug/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year: 69,422,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 60 mg/kg/3D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 99,282,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 20 mg/kg/45M-C
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 13,477,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,832,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2292 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,832,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 210 mg/kg/6W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,305,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84067 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 272 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84067 No. of Facilities: 42 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2047 (estimated) No. of Female Employees: 983 (estimated)
甲基泼尼松龙安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S22-S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
TU4146000
甲基泼尼松龙合成路线
甲基泼尼松龙文献
Chem. Res. Toxicol. 23 , 171-83, (2010)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...
Revival of physostigmine - a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients.Clin. Chem. Lab Med. 53 , 1259-64, (2015)
Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sep...
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
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¥588.0/1g
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产品详情:甲基泼尼松龙
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区域:上海市浦东新区
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¥需询单/1g
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产品详情:Methylprednisolone
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产品详情:Methylprednisolone
公司名:上海阿拉丁生化科技股份有限公司
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¥249.9/1ml
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联系人:阿拉丁李高志
产品详情:甲基泼尼松龙标准溶液
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¥263.0/1ml
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联系人:夏言
产品详情:[Perfemiker]甲醇中甲基泼尼松龙溶液标准物质,1.00mg/ml
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