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托瑞米芬

托瑞米芬用途

Toremifene (NK 622; FC 1157a)是第二代选择性雌激素受体调节剂,对雌激素受体的IC50为1μM。

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托瑞米芬名称

[ CAS 号 ]:
89778-26-7

[ 中文名 ]:
托瑞米芬

[ 英文名 ]:
Toremifene

[中文别名 ]:

涛瑞米芬

[英文别名 ]:

(Z)-Toremifene
MFCD00801070
Toremifene Base
Toremifene

托瑞米芬生物活性

[ 描述 ]:

Toremifene (NK 622; FC 1157a)是第二代选择性雌激素受体调节剂,对雌激素受体的IC50为1μM。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

[参考文献]

[1]. Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35.

[2]. Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene - Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108(1-2): 1-7.

[3]. Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31(5):523-9.

[相关活性小分子]

托瑞米芬物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
535.1±50.0 °C at 760 mmHg

[ 熔点 ]:
108-110°C

[ 分子式 ]:
C₂₆H₂₈ClNO

[ 分子量 ]:
405.960

[ 闪点 ]:
277.4±30.1 °C

[ 精确质量 ]:
405.185944

[ PSA ]:
12.47000

[ LogP ]:
7.82

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
2-8℃

托瑞米芬毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH2156700

CHEMICAL NAME :: Ethanamine, 2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-di methyl-, (Z)-

CAS REGISTRY NUMBER :: 89778-26-7

LAST UPDATED :: 199801

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C26-H28-Cl-N-O

MOLECULAR WEIGHT :: 406.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 360 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 mg/kg/13W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 90 mg/kg

SEX/DURATION :: female 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 36300 ug/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 18,303,1997 *** REVIEWS *** IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,367,1996 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,367,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,367,1996

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托瑞米芬安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R37:Irritating to the respiratory system. R43:May cause sensitization by skin contact.

[ 安全声明 (欧洲) ]:
S8-S24/25-S46

[ 危险品运输编码 ]:
UN 2210

[ RTECS号 ]:
ZB3200000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2922299090

托瑞米芬合成路线

详细合成路线

托瑞米芬制备

4-(2-二甲基氨基乙氧基)二苯甲酮和3-苯基丙烯醛，在氢化铝锂存在下缩合，在含氯化氢的乙醇溶液中回流脱水，生成烯键，最后氯化得到托瑞米芬。

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托瑞米芬海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

托瑞米芬

托瑞米芬用途

托瑞米芬名称

托瑞米芬生物活性

托瑞米芬物理化学性质

托瑞米芬毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

托瑞米芬安全信息

托瑞米芬合成路线

详细合成路线

托瑞米芬制备

托瑞米芬海关

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