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果胶酸

果胶酸用途

果酸(甲基原果胶)是一种聚半乳糖醛酸,可诱导垂体瘤细胞凋亡和坏死。果酸可用于癌症和自身免疫疾病的研究[2][3]。

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果胶酸名称

[ CAS 号 ]:
9046-40-6

[ 中文名 ]:
果胶酸

[ 英文名 ]:
Pectic acid

[英文别名 ]:

Poly(1,4-|A-D-galacturonate)
|A-D-Polygalacturonic acid

果胶酸生物活性

[ 描述 ]:

果酸(甲基原果胶)是一种聚半乳糖醛酸,可诱导垂体瘤细胞凋亡和坏死。果酸可用于癌症和自身免疫疾病的研究[2][3]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[体外研究]

果酸(2.5-100μg/mL,30分钟)刺激GH3/B6细胞中催乳素(PRL)的释放,而不影响细胞的活性[1]。通过MTT分析和AO/EB染色检测,果酸(100μg/mL-5 mg/mL,6-48 h)增加GH3/B6细胞的细胞死亡和DNA损伤[2]。果酸(100μg/mL-1 mg/mL,24小时)以剂量依赖性方式诱导GH3/B6细胞凋亡[2]。果酸(2.5-5 mg/mL,24小时)诱导GH3/B6细胞坏死,PI染色证实[2]。细胞周期分析[2]细胞株：GH3/B6细胞浓度：1 mg/mL孵育时间：24小时结果：诱导亚G1事件,DNA断裂,这与凋亡细胞的数量相关。

[体内研究]

果酸(25和100 mg/kg,口服灌胃)增加溃疡性结肠炎(UC)小鼠的结肠长度,降低疾病活动指数、组织病理学评分和促炎细胞因子水平[3]。果酸(6.25和12.5 mg/kg,静脉注射)可挽救UC小鼠结肠长度的缩短[3]。动物模型：溃疡性结肠炎(UC)小鼠[3]剂量：25100 mg/kg给药：口服灌胃结果：结肠最长,DAI最低,组织病理学评分最低。降低UC小鼠结肠组织中的促炎细胞因子。动物模型：溃疡性结肠炎(UC)小鼠[3]剂量：6.25,12.5 mg/kg给药：静脉注射结果：脾脏和胸腺指数降低。恢复UC小鼠脾脏和固有层的Th17/Treg平衡。改善肠道菌群组成。

[参考文献]

[1]. Delaram Eslimi, et al. Pectic acid effects on prolactin secretion in GH3/B6 rat pituitary cell line. Iran Biomed J. 2008 Jul;12(3):167-72.

[2]. Farnoosh Attari, et al. Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 2009 Oct;13(4):229-36.

[3]. Jie Song, et al. Effects of oral administration and intravenous injection of polygalacturonic acid on the immunomodulation and gut microbiota in UC mice. Int J Biol Macromol. 2022 Sep 30;217:150-160.

果胶酸物理化学性质

[ 分子式 ]:
C₁₈H₂₆O₁₉

[ 分子量 ]:
546.38800

[ 精确质量 ]:
546.10700

[ PSA ]:
319.89000

果胶酸MSDS

详细MSDS(安全技术说明书)

果胶酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

果胶酸文献

Substrate specificity of plant and fungi pectin methylesterases: Identification of novel inhibitors of PMEs.

Int. J. Biol. Macromol. 81 , 681-91, (2015)

Pectin methylesterases (PMEs) play a central role in pectin remodeling during plant development. They are also present in phytopathogens such as bacteria and fungi. We investigated the substrate speci...

Optimization of pectin extraction from banana peels with citric acid by using response surface methodology.

Food Chem. 198 , 113-8, (2016)

A central composite design was used to determine effects of pH (2.0-4.5), extraction temperature (70-90 °C) and time (120-240 min) on the yield, degree of methoxylation (DM) and galacturonic acid cont...

Pomegranate peel pectin films as affected by montmorillonite.

Food Chem. 198 , 107-12, (2016)

The industrial production of pomegranate juice has been favored by its alleged health benefits derived from its antioxidant properties. The processing of pomegranate juice involves squeezing juice fro...

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果胶酸