苯托沙敏
苯托沙敏用途
苯甲苯胺(Bistrimin)是一种具有镇静和镇痛作用的抗组胺药。苯基甲苯胺还具有强大的Sigma-1受体结合亲和力(Ki:160nM)[1][2][3]。
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苯托沙敏名称
[ CAS 号 ]:
92-12-6
[ 中文名 ]:
苯托沙敏
[ 英文名 ]:
phenyltoloxamine
[英文别名 ]:
- Feniltolossamina [DCIT]
- Phenyltoloxamine
- Phenoxadrine
- Antin
- [2-(2-benzyl-phenoxy)-ethyl]-dimethyl-amine
- Histionex
- 2-Dimethylamino-1-(2-benzyl-phenoxy)-aethan
- Bistrimin
- Phenoxadrin
- UNII-K65LB6598J
苯托沙敏生物活性
[ 描述 ]:
苯甲苯胺(Bistrimin)是一种具有镇静和镇痛作用的抗组胺药。苯基甲苯胺还具有强大的Sigma-1受体结合亲和力(Ki:160nM)[1][2][3]。
[ 相关类别 ]:
[ 靶点 ]
Sigma 1 Receptor:160 nM (Ki)
[体外研究]
苯基甲苯胺(10-50μM,24小时)在EVSA-T细胞中显示出细胞毒性[2]。苯基甲苯胺表现出强大的Sigma 1受体(S1R)结合亲和力,Ki值为160nM[3]。苯甲苯胺(100μM)抑制人肝巨细胞CYP2D6酶99.0%[4]。
苯托沙敏物理化学性质
[ 密度 ]:
1.022g/cm3
[ 沸点 ]:
359.2ºC at 760 mmHg
[ 分子式 ]:
C17H21NO
[ 分子量 ]:
255.35500
[ 闪点 ]:
106ºC
[ 精确质量 ]:
255.16200
[ PSA ]:
12.47000
[ LogP ]:
3.21780
[ 折射率 ]:
1.552
苯托沙敏毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KH2376000
- CHEMICAL NAME :
- Ethanamine, N,N-dimethyl-2-(2-(phenylmethyl)phenoxy)-
- CAS REGISTRY NUMBER :
- 92-12-6
- BEILSTEIN REFERENCE NO. :
- 1986598
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C17-H21-N-O
- MOLECULAR WEIGHT :
- 255.39
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1127 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 246 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83250 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)
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