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氟伐他汀

氟伐他汀用途

Fluvastatin (Leschol)能抑制HMG-CoA还原酶活性,IC50为8 nM。

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氟伐他汀名称

[ CAS 号 ]:
93957-54-1

[ 中文名 ]:
富伐他丁

[ 英文名 ]:
Fluvastatin

[中文别名 ]:

氟伐地汀

[英文别名 ]:

UNII:4L066368AS
fluvastatin
FLUVASTATIN NA
Lipaxan
MFCD00929076
Lescol
FLUVASTATIN SODIUM
Primexin

氟伐他汀生物活性

[ 描述 ]:

Fluvastatin (Leschol)能抑制HMG-CoA还原酶活性,IC50为8 nM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)

研究领域 >> 心血管疾病

[参考文献]

[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [Epub ahead of print]

[2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.

[3]. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.

[4]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.

[相关活性小分子]

氟伐他汀物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
681.8±55.0 °C at 760 mmHg

[ 熔点 ]:
194-197ºC

[ 分子式 ]:
C₂₄H₂₆FNO₄

[ 分子量 ]:
411.466

[ 闪点 ]:
366.1±31.5 °C

[ 精确质量 ]:
411.184601

[ PSA ]:
82.69000

[ LogP ]:
3.62

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.587

[ 储存条件 ]:
2-8℃

氟伐他汀毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9675050

CHEMICAL NAME :: 6-Heptenoic acid, 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl )- 3,5-dihydroxy-, (R*,S*-(E))-(+-)-

CAS REGISTRY NUMBER :: 93957-54-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H26-F-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 11648 mg/kg/2Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: LETRET Lens and Eye Toxicity Research. (Marcel Dekker, Journal Customer Service, POB 5017, Monticello, NY 12701) V.6n.1-2- 1989- Volume(issue)/page/year: 7,563,1990

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氟伐他汀安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R42/43:May cause sensitization by inhalation and skin contact .

[ 安全声明 (欧洲) ]:
S23-S26-S37

[ 危险品运输编码 ]:
UN 3272 3/PG 3

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
3

氟伐他汀

氟伐他汀用途

氟伐他汀名称

氟伐他汀生物活性

氟伐他汀物理化学性质

氟伐他汀毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

氟伐他汀安全信息

氟伐他汀合成路线

详细合成路线

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