< 生产厂家 价格 >

三醋酸甘油酯

三醋酸甘油酯用途

Triacetin是一种人工合成的化合物,是甘油和乙酸的三酯。
点击显示

三醋酸甘油酯名称

[ CAS 号 ]:
102-76-1

[ 中文名 ]:
三醋精

[ 英文名 ]:
Triacetin

[中文别名 ]:

[英文别名 ]:

三醋酸甘油酯生物活性

[ 描述 ]:

Triacetin是一种人工合成的化合物,是甘油和乙酸的三酯。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 其他

[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

三醋酸甘油酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
258.0±0.0 °C at 760 mmHg

[ 熔点 ]:
3 °C(lit.)

[ 分子式 ]:
C9H14O6

[ 分子量 ]:
218.204

[ 闪点 ]:
148.9±0.0 °C

[ 精确质量 ]:
218.079041

[ PSA ]:
78.90000

[ LogP ]:
-0.24

[ 外观性状 ]:
无色液体带有一种苦味道

[ 蒸汽密度 ]:
7.52 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.435

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
64.0 g/L (20 ºC)

三醋酸甘油酯MSDS

详细MSDS(安全技术说明书)

三醋酸甘油酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK3675000
CHEMICAL NAME :
Acetin, tri-
CAS REGISTRY NUMBER :
102-76-1
BEILSTEIN REFERENCE NO. :
1792353
LAST UPDATED :
199701
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C9-H14-O6
MOLECULAR WEIGHT :
218.23
WISWESSER LINE NOTATION :
1VO1YOV1&1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,377,1944 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,879,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 46,26,1941
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Behavioral - stiffness
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 22,368,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Behavioral - stiffness
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 22,368,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 46,26,1941
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940- Volume(issue)/page/year: 40,338,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,879,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,879,1978
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1740 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,189,1942
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,879,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1910 No. of Facilities: 832 (estimated) No. of Industries: 17 No. of Occupations: 25 No. of Employees: 11313 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1910 No. of Facilities: 713 (estimated) No. of Industries: 13 No. of Occupations: 21 No. of Employees: 18436 (estimated) No. of Female Employees: 4103 (estimated)
点击显示

三醋酸甘油酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
AK3675000

[ 海关编码 ]:
2915390090

三醋酸甘油酯合成路线

详细合成路线

三醋酸甘油酯上下游产品

三醋酸甘油酯上游产品

三醋酸甘油酯下游产品

三醋酸甘油酯制备

1、由甘油与乙酸酯化而得。将甘油预热到50-60℃后，加入乙酸、苯和硫酸。加热搅拌回流脱水，脱水完后回收苯，再加入乙酐，加热4h。冷却后用5%碳酸钠中和pH至7，分去水层，粗油用氯化钙干燥。减压蒸馏，收集128-131℃（0.93kPa）馏分，即为甘油三乙酸酯。 2、由醋酐与热甘油酯化后经真空蒸馏提纯而得。 3. 酯化反应　向塔釜中分别加入一定量的甘油、冰醋酸（醇酸摩尔比为1∶4）、固载型杂多酸催化剂（醇质量的2.5%）和带水剂甲苯（温度调节剂），加热塔釜液，使釜液处于微沸或沸腾状态下，进行反应精馏操作。塔顶分水器中的酯相返回精馏塔，水相采出。当塔顶分水器无水滴分出时，向塔釜中加入一定量的醋酐，继续反应4h后，终止酯化反应，冷却后，即得粗酯。 4. 粗酯精制　粗酯经冷却，过滤出固体催化剂滤液。先进行常压精馏，回收过量的冰醋酸和带水剂甲苯，当馏出液很少时改为减压精馏，进一步脱除冰醋酸，控制釜液温度在100～120℃以内，无馏出液时停止蒸馏操作；釜液温度降至100℃以内，加入一定量的脱色剂活性炭，搅拌一定时间后，冷却，滤出脱色剂，得产品三醋酸甘油酯。
点击显示

三醋酸甘油酯海关

[ 海关编码 ]: 2915390090

[ 中文概述 ]:
2915390090. 其他乙酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

三醋酸甘油酯文献

Biodegradable injectable in situ implants and microparticles for sustained release of montelukast: in vitro release, pharmacokinetics, and stability.

AAPS PharmSciTech 15(3) , 772-80, (2014)

The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ ...

Plasticization effect of triacetin on structure and properties of starch ester film.

Carbohydr. Polym. 94(2) , 874-81, (2013)

The aim of this work was to evaluate the plasticizing effect of triacetin on the structure and properties of starch ester film and further establish the structure-property relationships. The presence ...

Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation.

Int. J. Pharm. 475(1-2) , 191-7, (2014)

Saquinavir mesylate (SM) is a protease inhibitor with activity against human immunodeficiency virus type 1 (HIV-1) and is available in tablet form, which has three major problems. First, the drug unde...


更多文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：三醋酸甘油酯

公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：甘油三乙酸酯

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥78.0/500ml

联系人：刘佳

产品详情：三乙酸甘油酯

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Triacetin

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥73.0/500ml ￥275.0/2500g ￥804.0/10kg

联系人：夏言

产品详情：[Perfemiker]三乙酸甘油酯,AR，98.5%

查看所有供应商请点击：

三醋酸甘油酯供应商

三醋酸甘油酯相关知识

三乙酸甘油酯_用途_制备_检测

2022-05-06 17:27:01

三乙酸甘油酯又称Triacetin。从乙醇中析出者为无色立方晶体，或无色油状液体。有轻微的油脂气味，溶于水(7)、乙醇、乙醚、丙酮、苯和氯仿。由乙酸和甘油在硫酸存在下进行酯化，可制得三乙酸甘油酯。三乙酸甘油酯在我国消耗量在万吨以上，是一种十分走俏的化工原料。当前生产中亟待解决的问题是由于用硫酸作均...

相关化合物

【三醋酸甘油酯】化源网提供三醋酸甘油酯CAS号102-76-1，三醋酸甘油酯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询三醋酸甘油酯上化源网，专业又轻松。>>电脑版：三醋酸甘油酯

标题：三醋酸甘油酯_MSDS_用途_密度_三醋酸甘油酯CAS号【102-76-1】_化源网 地址：https://m.chemsrc.com/mip/cas/102-76-1_335865.html