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2-甲基-6-(苯基乙炔基)吡啶

2-甲基-6-(苯基乙炔基)吡啶用途

MPEP是mGlu5受体非竞争性拮抗剂,IC50为36 nM,还是mGlu4受体的正向变构调节剂。

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2-甲基-6-(苯基乙炔基)吡啶名称

[ CAS 号 ]:
96206-92-7

[ 中文名 ]:
2-甲基-6-(苯乙炔)吡啶盐酸盐

[ 英文名 ]:
MPEP

[中文别名 ]:

[英文别名 ]:

2-Methyl-6-(phenylethynyl)pyridine hydrochloride
MPEP,HCl
MFCD02262119
MPEP
2-methyl-6-phenylethynyl-pyridine
2-Methyl-6-phenylaethinyl-pyridin

2-甲基-6-(苯基乙炔基)吡啶生物活性

[ 描述 ]:

MPEP是mGlu5受体非竞争性拮抗剂,IC50为36 nM,还是mGlu4受体的正向变构调节剂。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

[2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.

[3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

[相关活性小分子]

2-甲基-6-(苯基乙炔基)吡啶物理化学性质

[ 沸点 ]:
336.3ºC at 760mmHg

[ 分子式 ]:
C₁₄H₁₁N

[ 分子量 ]:
193.24

[ 闪点 ]:
144.8ºC

[ PSA ]:
12.89000

[ LogP ]:
3.59180

[ 储存条件 ]:
Desiccate at +4°C

2-甲基-6-(苯基乙炔基)吡啶安全信息

[ 海关编码 ]:
2933399090

2-甲基-6-(苯基乙炔基)吡啶合成路线

详细合成路线

2-甲基-6-(苯基乙炔基)吡啶上下游产品

2-甲基-6-(苯基乙炔基)吡啶上游产品

2-甲基-6-(苯基乙炔基)吡啶下游产品

2-甲基-6-(苯基乙炔基)吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%