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L-精氨酰甘氨酰-L-天冬氨酸

L-精氨酰甘氨酰-L-天冬氨酸用途

RGD Trifluoroacetate 是一种三肽，能够有效的引起细胞黏着，定位某种特定细胞系并产生特定的细胞反应；能够与 integrins 结合。

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L-精氨酰甘氨酰-L-天冬氨酸名称

[ CAS 号 ]:
99896-85-2

[ 中文名 ]:
精氨酰-甘氨酰-天冬氨酸

[ 英文名 ]:
H-Arg-Gly-Asp-OH

[中文别名 ]:

RGD肽

[英文别名 ]:

L-Aspartic acid, L-arginylglycyl-
F-336
L-Arginylglycyl-L-aspartic acid
Arg-Gly-Asp (RGD)
arginyl-glycyl-aspartic acid
l-arginylglycylaspartic acid
RGD
Arg-Gly-Asp acetate
H2N-RGD-OH
MFCD00057952

L-精氨酰甘氨酰-L-天冬氨酸生物活性

[ 描述 ]:

RGD Trifluoroacetate 是一种三肽,能够有效的引起细胞黏着,定位某种特定细胞系并产生特定的细胞反应；能够与 integrins 结合。

[ 相关类别 ]:

信号通路 >> 细胞骨架 >> Integrin

研究领域 >> 癌症

多肽产品

[ 靶点 ]

Integrin[1]

[体外研究]

RGD三氟乙酸盐是最有效和最常用的肽序列,用于在合成表面上刺激细胞粘附。有24种整合素以RGD依赖性方式与ECM分子结合：α3β1,α5β1,α8β1,αIIbβ3,αvβ1,αvβ3,αvβ5,αvβ6,αvβ8,并且在某种程度上α2β1和α4β1[1]。

[参考文献]

[1]. Hersel U, et al. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003 Nov;24(24):4385-415.

[相关活性小分子]

L-精氨酰甘氨酰-L-天冬氨酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 熔点 ]:
153-155℃ (ethyl ether )

[ 分子式 ]:
C₁₂H₂₂N₆O₆

[ 分子量 ]:
346.340

[ 精确质量 ]:
346.160095

[ PSA ]:
220.72000

[ LogP ]:
-1.94

[ 折射率 ]:
1.648

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble in 0.1N acetic acid at 20mg/ml

L-精氨酰甘氨酰-L-天冬氨酸MSDS

L-精氨酰甘氨酰-L-天冬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925290090

L-精氨酰甘氨酰-L-天冬氨酸合成路线

L-精氨酰甘氨酰-L-天冬氨酸上下游产品

L-精氨酰甘氨酰-L-天冬氨酸上游产品

L-精氨酰甘氨酰-L-天冬氨酸下游产品

L-精氨酰甘氨酰-L-天冬氨酸海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

L-精氨酰甘氨酰-L-天冬氨酸文献

Coculture of dorsal root ganglion neurons and differentiated human corneal stromal stem cells on silk-based scaffolds.

J. Biomed. Mater. Res. A 103 , 3339-48, (2015)

Corneal tissue displays the highest peripheral nerve density in the human body. Engineering of biomaterials to promote interactions between neurons and corneal tissue could provide tissue models for n...

Inducing cells to disperse nickel nanowires via integrin-mediated responses.

Nanotechnology 26(13) , 135102, (2015)

We present non-cytotoxic, magnetic, Arg-Gly-Asp (RGD)-functionalized nickel nanowires (RGD-nanowires) that trigger specific cellular responses via integrin transmembrane receptors, resulting in disper...

Improved tumor-targeting MRI contrast agents: Gd(DOTA) conjugates of a cycloalkane-based RGD peptide.

Biochem. Biophys. Res. Commun. 455(3-4) , 246-50, (2014)

Two new MRI contrast agents, Gd-DOTA-c(RGD-ACP-K) (1) and Gd-DOTA-c(RGD-ACH-K) (2), which were designed by incorporating aminocyclopentane (ACP)- or aminocyclohexane (ACH)-carboxylic acid into Gd-DOTA...

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