头孢曲松钠
头孢曲松钠用途
【用途一】
用于治疗呼吸道感染、泌尿系统感染、淋病及术前感染预防
用于治疗呼吸道感染、泌尿系统感染、淋病及术前感染预防
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头孢曲松钠作用
该药品为半合成的第三代头孢菌素，对大多数革兰阳性菌和阴性菌都有强大抗菌活性，抗菌谱包括绿脓杆菌、大肠杆菌、肺炎杆菌、流感嗜血杆菌、产气肠细菌、变形杆菌属、双球菌属及金葡菌等。该药品对β内酰胺酶稳定。
临床主要用于敏感菌感染的脑膜炎、肺炎、皮肤软组织感染、腹膜炎、泌尿系统感染、淋病、肝胆感染、外科创伤，败血症及生殖器感染等。已作为治疗淋病的第一线药物。
临床主要用于敏感菌感染的脑膜炎、肺炎、皮肤软组织感染、腹膜炎、泌尿系统感染、淋病、肝胆感染、外科创伤，败血症及生殖器感染等。已作为治疗淋病的第一线药物。
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头孢曲松钠名称
[ CAS 号 ]:
74578-69-1
[ 中文名 ]:
头孢曲松钠
[ 英文名 ]:
Ceftriaxone sodium
[中文别名 ]:
[英文别名 ]:
- Ceftriaxone disodium
- x13-9904
- rocephin
- ceftriaxone
- Longaceph
- cefatriaxonehydrate
- MFCD00865013
- cephtriaxone
- Ceftriaxone sodium
- ro13-9904
头孢曲松钠生物活性
[ 描述 ]:
Ceftriaxone钠盐是抗细菌感染的抗生素。
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
头孢曲松钠物理化学性质
[ 分子式 ]:
C18H16N8Na2O7S3
[ 分子量 ]:
598.544
[ 精确质量 ]:
598.009949
[ PSA ]:
296.63000
[ 储存条件 ]:
2-8C
头孢曲松钠毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0368800
- CAS REGISTRY NUMBER :
- 74578-69-1
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C18-H16-N8-O7-S3.2Na.7/2H2-O
- MOLECULAR WEIGHT :
- 661.63
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 16 mg/kg/3D-I
- TOXIC EFFECTS :
- Brain and Coverings - meningeal changes Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,360,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 640 mg/kg/32D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - agranulocytosis Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 29,52,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 800 mg/kg/49D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis Blood - changes in leukocyte (WBC) count
- REFERENCE :
- IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 29,52,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin, Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep. Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin, Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep. Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin, Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep. Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin, Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep. Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin, Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep. Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,783,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 51450 mg/kg/42D-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure) Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 18,1751,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42875 mg/kg/5W-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 18,1793,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 21840 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - change in gall bladder structure or function Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 18,1855,1984
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头孢曲松钠安全信息
[ 海关编码 ]:
3004909090
头孢曲松钠上下游产品
头孢曲松钠上游产品
头孢曲松钠下游产品
头孢曲松钠海关
[ 海关编码 ]: 3004909090
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥218.0/100mg
￥248.0/5g
联系人：刘佳
产品详情：头孢曲松钠
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Ceftriaxone Sodium
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥560.0/5g
￥909.0/1g
￥需询单/1g
￥110.0/100mg
联系人：阿拉丁李高志
产品详情：头孢曲松钠
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥122.0/100mg
￥383.0/1g
￥616.0/5g
￥1000.0/25g
联系人：夏言
产品详情：[Perfemiker]头孢曲松钠,HPLC≥98%
公司名：湖北魏氏化学试剂股份有限公司
区域：武汉市洪山区
价格：
￥需询单/5mg
￥需询单/25mg
￥需询单/10g
￥需询单/50g
联系人：张栋
产品详情：头孢曲松钠
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相关化合物
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