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头孢噻肟钠

头孢噻肟钠用途

头孢噻肟钠(Cefotaxim sodium salt)是第三代头孢类抗生素,广谱抗生素。
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头孢噻肟钠名称

[ CAS 号 ]:
64485-93-4

[ 中文名 ]:
头孢噻肟钠

[ 英文名 ]:
cefotaxime sodium

[中文别名 ]:

[英文别名 ]:

头孢噻肟钠生物活性

[ 描述 ]:

头孢噻肟钠(Cefotaxim sodium salt)是第三代头孢类抗生素,广谱抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染

[参考文献]

[1]. Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9.

[2]. Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7.

[3]. Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42(1):71-9.


[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 氯霉素

头孢噻肟钠物理化学性质

[ 密度 ]:
1.8 g/cm3

[ 熔点 ]:
162-163ºC(lit.)

[ 分子式 ]:
C16H16N5NaO7S2

[ 分子量 ]:
477.447

[ 精确质量 ]:
477.038879

[ PSA ]:
229.88000

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 折射率 ]:
61 ° (C=1， H2O)

[ 储存条件 ]:
库房低温通风干燥

头孢噻肟钠MSDS

详细MSDS(安全技术说明书)

头孢噻肟钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI0250000
CHEMICAL NAME :
5-Thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino- 4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6-alpha,7-beta(Z))), sodium salt
CAS REGISTRY NUMBER :
64485-93-4
LAST UPDATED :
199609
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C16-H16-N5-O7-S2.Na
MOLECULAR WEIGHT :
477.48
WISWESSER LINE NOTATION :
T46 ANV ES GUTJ G1OV1 HVO CMVYUNO1&- ET5N CSJ BZ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
1800 mg/kg/18D-I
TOXIC EFFECTS :
Blood - agranulocytosis
REFERENCE :
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 17,739,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18400 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-8,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-8,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-8,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6845 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(5),25,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 6(Suppl A),79,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>716 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1880 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 gm/kg/30D-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7560 mg/kg/2W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(5),25,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10080 mg/kg/4W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(5),25,1990 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
325 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,375,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5623 No. of Facilities: 44 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8498 (estimated) No. of Female Employees: 7477 (estimated)
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头孢噻肟钠安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S22-S36-S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XI0250000

[ 海关编码 ]:
29419000

头孢噻肟钠合成路线

详细合成路线

头孢噻肟钠上下游产品

头孢噻肟钠上游产品

头孢噻肟钠下游产品

头孢噻肟钠制备

1.55.6g化合物(工)和24.3g三乙胺溶于600ml二氯甲烷，在冰浴冷却下，分2次加入41.8g五氯化磷。5min后移去冰浴，再在室温下搅拌20min。减压浓缩，剩余物加入1L正己烷进行剧烈搅拌。用倾析法倒去正己烷，分出沉淀的油状物，并溶于600ml四氢呋喃。过滤除去析出的三乙胺盐酸盐，得化合物(Ⅱ)的四氢呋喃溶液，直接用于下面的反应。
10.0g 7姚和11.0g三乙胺溶于120rnl 50%四氢呋喃水溶液，在冰浴冷却下，滴加化合物(Ⅱ)的四氢呋喃溶液(从10.0g化合物(I)。制得)，加毕再在室温下搅拌1h。加入水和乙酸乙酯，水层用磷酸调至Ph=2.0。摇晃后分出有机层，水层用乙酸乙酯提取。有机层合并，常规处理后，得10.7g粉末状的化合物(Ⅲ)。


2.将化合物(Ⅲ)溶于40ml二甲基乙酰胺(DMA)，加入3.40g硫脲，在室温搅拌15h。倾人冰水，用碳酸氢钠调至Ph=3.5。过滤收集析出的固体，溶于5%碳酸氢钠水溶液，用Amberlite XAD-2进行层析，用水再用2%乙醇水溶液洗脱，冻干后得4.20g无色粉末状的头孢噻肟钠。
方法2：8g碳酸氢钠溶于20ml乙醇，连续加入45.55g 3-乙酰氧甲基-7-[2-(2-氨基-4-噻唑基)-2-甲氧亚氨基乙酰胺基]头孢-3稍-4-羧酸(头孢噻肟)溶于100ml蒸馏水中所成的溶液，然后加入80rnl乙醇和4.5g活性炭，搅拌5min后，过滤。滤饼用乙醇洗，滤液减压浓缩至于，剩余物溶于：100ml乙醇，再浓缩至干。剩余物溶于100ml甲醇，倾入2L丙酮中。剧烈搅拌所成的溶液，并减压过滤，固体先用丙酮后用乙醚略加洗涤，真空干燥，得到43.7g白色的头孢噻肟钠。该头孢噻肟钠在空气中吸湿，吸湿后的重量为45.2g，为头孢噻肟钠的水合物。

3.以7-ACA(7-氨基头孢烷酸)为原料，先和三嗪环缩合成7-ACT，再与氨噻肟活性酯(含磷活性酯或巯基杂环活性酯)缩合形成头孢三嗪。用含磷活性酯时，必须先用单三甲基乙酰胺或双甲基硅脲等硅烷化试剂把7-ACT上的羧基和羟基保护起来，它的缩合产物是头孢三嗪酸，须再经成盐反应方能成为头孢三嗪双钠盐。用巯基杂环活性酯时，则不需预先保护羧基，且缩合产物一步成盐，因此该工业更简单。
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头孢噻肟钠海关

[ 海关编码 ]: 29419000

头孢噻肟钠文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

[Generalized cutaneous candidiasis in newborn at term].

Biomedica. 32(2) , 170-3, (2012)

Cutaneous candidiasis is a disease that affects children as well as adults. The presentation may be localized or systemic, and with multiple etiological agents. The most prevalent infecting species in...

83-year-old man with abdominal swelling and lower extremity edema.

Mayo Clin. Proc. 88(10) , e115-8, (2013)


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推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：噻孢霉素

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥118.0/1g ￥347.0/5g

联系人：刘佳

产品详情：头孢噻肟钠

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Cefotaxime Sodium

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥469.0/1g ￥749.0/5g ￥489.0/1g ￥需询单/1g

联系人：李先生

产品详情：Cefotaxime (sodium salt)

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥91.0/250mg ￥143.0/1g ￥310.0/5g ￥556.0/25g

联系人：夏言

产品详情：[Perfemiker]头孢噻肟钠,≥98%（HPLC)

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相关化合物

【头孢噻肟钠】化源网提供头孢噻肟钠CAS号64485-93-4，头孢噻肟钠MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询头孢噻肟钠上化源网，专业又轻松。>>电脑版：头孢噻肟钠

标题：头孢噻肟钠_MSDS_用途_密度_头孢噻肟钠CAS号【64485-93-4】_化源网 地址：https://m.chemsrc.com/mip/cas/64485-93-4_121032.html