头孢噻肟钠
头孢噻肟钠用途
头孢噻肟钠名称
[ CAS 号 ]:
64485-93-4
[ 中文名 ]:
头孢噻肟钠
[ 英文名 ]:
cefotaxime sodium
[中文别名 ]:
[英文别名 ]:
- hr756
- Cefotaxime Na
- sodium cefotaxime
- FIR-756
- ctx
- EINECS 264-915-9
- Chemcef
- Cefotax
- CLAFORAN
- Pretor
头孢噻肟钠生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
头孢噻肟钠物理化学性质
[ 密度 ]:
1.8 g/cm3
[ 熔点 ]:
162-163ºC(lit.)
[ 分子式 ]:
C16H16N5NaO7S2
[ 分子量 ]:
477.447
[ 精确质量 ]:
477.038879
[ PSA ]:
229.88000
[ 外观性状 ]:
白色至淡黄色结晶粉末
[ 折射率 ]:
61 ° (C=1， H2O)
[ 储存条件 ]:
库房低温通风干燥
头孢噻肟钠MSDS
头孢噻肟钠毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0250000
- CHEMICAL NAME :
- 5-Thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino- 4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6-alpha,7-beta(Z))), sodium salt
- CAS REGISTRY NUMBER :
- 64485-93-4
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C16-H16-N5-O7-S2.Na
- MOLECULAR WEIGHT :
- 477.48
- WISWESSER LINE NOTATION :
- T46 ANV ES GUTJ G1OV1 HVO CMVYUNO1&- ET5N CSJ BZ &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 1800 mg/kg/18D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 17,739,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18400 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-8,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-8,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-8,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6845 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(5),25,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 6(Suppl A),79,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >716 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1880 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 gm/kg/30D-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 1),98,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7560 mg/kg/2W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(5),25,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10080 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(5),25,1990 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 325 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,375,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5623 No. of Facilities: 44 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8498 (estimated) No. of Female Employees: 7477 (estimated)
头孢噻肟钠安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H317-H334
[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R42/43
[ 安全声明 (欧洲) ]:
S22-S36-S37
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
XI0250000
[ 海关编码 ]:
29419000
头孢噻肟钠合成路线
头孢噻肟钠上下游产品
头孢噻肟钠上游产品
头孢噻肟钠下游产品
头孢噻肟钠制备
1.55.6g化合物(工)和24.3g三乙胺溶于600ml二氯甲烷，在冰浴冷却下，分2次加入41.8g五氯化磷。5min后移去冰浴，再在室温下搅拌20min。减压浓缩，剩余物加入1L正己烷进行剧烈搅拌。用倾析法倒去正己烷，分出沉淀的油状物，并溶于600ml四氢呋喃。过滤除去析出的三乙胺盐酸盐，得化合物(Ⅱ)的四氢呋喃溶液，直接用于下面的反应。
10.0g 7姚和11.0g三乙胺溶于120rnl 50%四氢呋喃水溶液，在冰浴冷却下，滴加化合物(Ⅱ)的四氢呋喃溶液(从10.0g化合物(I)。制得)，加毕再在室温下搅拌1h。加入水和乙酸乙酯，水层用磷酸调至Ph=2.0。摇晃后分出有机层，水层用乙酸乙酯提取。有机层合并，常规处理后，得10.7g粉末状的化合物(Ⅲ)。
2.将化合物(Ⅲ)溶于40ml二甲基乙酰胺(DMA)，加入3.40g硫脲，在室温搅拌15h。倾人冰水，用碳酸氢钠调至Ph=3.5。过滤收集析出的固体，溶于5%碳酸氢钠水溶液，用Amberlite XAD-2进行层析，用水再用2%乙醇水溶液洗脱，冻干后得4.20g无色粉末状的头孢噻肟钠。
方法2：8g碳酸氢钠溶于20ml乙醇，连续加入45.55g 3-乙酰氧甲基-7-[2-(2-氨基-4-噻唑基)-2-甲氧亚氨基乙酰胺基]头孢-3稍-4-羧酸(头孢噻肟)溶于100ml蒸馏水中所成的溶液，然后加入80rnl乙醇和4.5g活性炭，搅拌5min后，过滤。滤饼用乙醇洗，滤液减压浓缩至于，剩余物溶于：100ml乙醇，再浓缩至干。剩余物溶于100ml甲醇，倾入2L丙酮中。剧烈搅拌所成的溶液，并减压过滤，固体先用丙酮后用乙醚略加洗涤，真空干燥，得到43.7g白色的头孢噻肟钠。该头孢噻肟钠在空气中吸湿，吸湿后的重量为45.2g，为头孢噻肟钠的水合物。
3.以7-ACA(7-氨基头孢烷酸)为原料，先和三嗪环缩合成7-ACT，再与氨噻肟活性酯(含磷活性酯或巯基杂环活性酯)缩合形成头孢三嗪。用含磷活性酯时，必须先用单三甲基乙酰胺或双甲基硅脲等硅烷化试剂把7-ACT上的羧基和羟基保护起来，它的缩合产物是头孢三嗪酸，须再经成盐反应方能成为头孢三嗪双钠盐。用巯基杂环活性酯时，则不需预先保护羧基，且缩合产物一步成盐，因此该工业更简单。
头孢噻肟钠海关
[ 海关编码 ]: 29419000
头孢噻肟钠文献
Nat. Chem. Biol. 3(5) , 268-273, (2007)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...
[Generalized cutaneous candidiasis in newborn at term].Biomedica. 32(2) , 170-3, (2012)
Cutaneous candidiasis is a disease that affects children as well as adults. The presentation may be localized or systemic, and with multiple etiological agents. The most prevalent infecting species in...
83-year-old man with abdominal swelling and lower extremity edema.Mayo Clin. Proc. 88(10) , e115-8, (2013)
相关化工产品/化学物质：
相关药品：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥118.0/1g
￥347.0/5g
联系人：刘佳
产品详情：头孢噻肟钠
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Cefotaxime Sodium
公司名：上海脉铂医药科技有限公司
区域：上海市嘉定区
价格：
￥469.0/1g
￥749.0/5g
￥489.0/1g
￥需询单/1g
联系人：李先生
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥91.0/250mg
￥143.0/1g
￥310.0/5g
￥556.0/25g
联系人：夏言
产品详情：[Perfemiker]头孢噻肟钠,≥98%（HPLC)
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥164.9/1g
￥61.9/250mg
￥41.9/50mg
￥257.9/5g
联系人：阿拉丁李高志
产品详情：头孢噻肟钠盐
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相关化合物
【头孢噻肟钠】化源网提供头孢噻肟钠CAS号64485-93-4，头孢噻肟钠MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询头孢噻肟钠上化源网，专业又轻松。>>电脑版：头孢噻肟钠
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