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衣霉素

衣霉素用途

Tunicamycin是来自Streptomyces lysosuperijkus的含有N-乙酰氨基葡糖的抗生素,抑制蛋白质糖基化。

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衣霉素名称

[ CAS 号 ]:
11089-65-9

[ 中文名 ]:
衣霉素

[ 英文名 ]:
Tunicamycin

[中文别名 ]:

链病毒菌素

[英文别名 ]:

TUNICAMYCIN,STREPTOMYCES LYSOSUPERFICUS
MFCD00065709
Tunicamycin Streptomyces sp.
TUNICAMYCIN

衣霉素生物活性

[ 描述 ]:

Tunicamycin是来自Streptomyces lysosuperijkus的含有N-乙酰氨基葡糖的抗生素,抑制蛋白质糖基化。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 炎症/免疫

[参考文献]

[1]. Nami B et al. Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells. Exp Toxicol Pathol. 2016 Aug;68(7):419-26.

[2]. Guo Q et al. Tunicamycin Aggravates Endoplasmic Reticulum Stress and Airway Inflammation via PERK-ATF4-CHOP Signaling in a Murine Model of Neutrophilic Asthma. J Asthma. 2016 Jul 6

[相关活性小分子]

衣霉素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
234 - 235ºC

[ 分子式 ]:
C₃₉H₆₄N₄O₁₆(n=₁₀)

[ 分子量 ]:
844.94 (n=10)

[ PSA ]:
311.82000

[ LogP ]:
2.58

[ 外观性状 ]:
白色结晶固体

[ 折射率 ]:
1.617

[ 储存条件 ]:
2~8°C

衣霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YO7980200

CHEMICAL NAME :: Tunicamycin

CAS REGISTRY NUMBER :: 11089-65-9

LAST UPDATED :: 199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 500 ug/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 4 ug/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,1148,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0225 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 80 (estimated) No. of Female Employees: 30 (estimated)

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衣霉素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
28

[ 安全声明 (欧洲) ]:
28-37/39-45

[ 危险品运输编码 ]:
UN 3462 6

[ WGK德国 ]:
3

[ RTECS号 ]:
YO7980200

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29419090

衣霉素文献

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.

J. Biol. Chem. 290 , 14361-80, (2015)

Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy. The mecha...

RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.

Autophagy 11 , 975-94, (2015)

Although RIPK1 (receptor [TNFRSF]-interacting protein kinase 1) is emerging as a critical determinant of cell fate in response to cellular stress resulting from activation of death receptors and DNA d...

Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies.

J. Immunol. 195 , 5178-88, (2015)

B cell binding and cytotoxicity by human VH4-34-encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early response in a phase 1 trial for treatment of ...

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衣霉素