< 生产厂家价格 >

潮霉素B

潮霉素B用途

Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。

点击显示

潮霉素B名称

[ CAS 号 ]:
31282-04-9

[ 中文名 ]:
潮霉素 B

[ 英文名 ]:
Hygromycin B

[中文别名 ]:

[英文别名 ]:

Destomycin A
EINECS 250-545-5
HYGROGOLD(TM)
hygrovetine
Hygromix
Hygromix-8
antihelmycin
hygromix2.4
Hygrovetin
MFCD00036846

潮霉素B生物活性

[ 描述 ]:

Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[ 靶点 ]

Target：Antibacterial; Antifungal[1]

[体外研究]

Hygromycin B是一种强烈抑制70S和80S核糖体的氨基环醇抗生素,由吸水链霉菌(Streptomyces hygroscopicus)合成[1]。 0.38mM浓度的潮霉素B完全阻止富含培养基中的酵母细胞生长,可能是通过细胞质核糖体阻止蛋白质合成。来自兔网织红细胞,小麦胚芽和酵母的无细胞提取物中的多肽合成被低浓度的潮霉素B强烈阻断。抗生素通过预防延伸因子EF-2依赖性易位来抑制酵母多核糖体的肽链延伸。潮霉素B对易位的抑制可能是由于与核糖体受体位点结合的肽基-tRNA的稳定作用[2]。

[体内研究]

潮霉素B通过阻断核糖体易位来抑制蛋白质合成,而不会在体内引起显着的误读[3]。在体内转基因小鼠中细菌hygR基因的组成型表达赋予对潮霉素B的抗性[4]。

[动物实验]

将潮霉素B溶于无菌水中。携带hygR的小鼠C57BL / 6J-TgN（pPWL512hyg）1Ems用单剂量的潮霉素B ip处理，剂量开始为2.7mg / kg，并且每次连续剂量增加50％。用相同体积的无菌盐水处理对照野生型C57BL / 6J小鼠。注射的总体积为0.5mL。每天监测动物的健康状况和体重，连续10天[4]。

[相关活性小分子]

潮霉素B物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
897.6±65.0 °C at 760 mmHg

[ 熔点 ]:
160-180ºC

[ 分子式 ]:
C₂₀H₃₇N₃O₁₃

[ 分子量 ]:
527.520

[ 闪点 ]:
496.7±34.3 °C

[ 精确质量 ]:
527.232666

[ PSA ]:
272.06000

[ LogP ]:
0.64

[ 外观性状 ]:
非晶形的固体或黄褐色的粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.672

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
水溶性：完全溶解；易溶于：甲醇,乙醇

潮霉素BMSDS

详细MSDS(安全技术说明书)

潮霉素B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2130000

CHEMICAL NAME :: D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosyli dene-(1-2-3)-O-beta-D- talopyranosyl-(1-5)-2-deoxy-N-(sup 3)-methyl-

CAS REGISTRY NUMBER :: 31282-04-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C20-H37-N3-O13

MOLECULAR WEIGHT :: 527.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2220 ug/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46000 units/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 378 mg/kg/17W-I

TOXIC EFFECTS :: Blood - changes in spleen

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 3 gm/L

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 25,822,1980 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.001 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2770 No. of Facilities: 71 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 357 (estimated)

点击显示

潮霉素B安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H318-H330-H334

[ 警示性声明 ]:
P260-P280-P284-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R26/27/28;R41;R42/43

[ 安全声明 (欧洲) ]:
S22-S26-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3462

[ WGK德国 ]:
3

[ RTECS号 ]:
WK2130000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

潮霉素B制备

1、由吸水链霉菌（Streptomyces hygroscopicus）发酵生产。

点击显示

潮霉素B文献

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.

Mol. Cancer 13 , 259, (2014)

Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PI...

Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival.

Stem Cell Res. 12(2) , 584-98, (2014)

The hTERT-immortalization of human bone marrow-derived Mesenchymal Stromal Cells (hMSCs) was proposed to address availability/standardization issues for experimental or clinical studies, but raised co...

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells.

EMBO J. 31(18) , 3678-90, (2012)

The eukaryotic genome is replicated according to a specific spatio-temporal programme. However, little is known about both its molecular control and biological significance. Here, we identify mouse Ri...

更多文献

潮霉素B

潮霉素B用途

潮霉素B名称

潮霉素B生物活性

潮霉素B物理化学性质

潮霉素BMSDS

详细MSDS(安全技术说明书)

潮霉素B毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

潮霉素B安全信息

潮霉素B制备

潮霉素B文献

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

相关化合物