三七皂苷R1

J. Agric. Food Chem. 63(9) , 2413-22, (2015)

The aim of present study was to evaluate the effects of Panax notoginseng saponins (PNS) against acute ethanol-induced liver injury and further to elucidate its probable mechanisms. Mice were treated with PNS (100 or 300 mg/kg) once daily for seven consecutiv...

J. Pharm. Biomed. Anal. 102 , 78-84, (2014)

The step of enriching and purifying saponins by macroporous resin column chromatography is closely related to the safety and efficacy of Panax notoginseng products during their manufacturing processes. Adsorption process is one of the most critical unit opera...

J. Pharm. Biomed. Anal. 99 , 8-15, (2014)

American ginseng (Panax quinquefolius) is originally grown in North America. Due to price difference and supply shortage, American ginseng recently has been cultivated in northern China. Further, in the market, some Asian ginsengs are labeled as American gins...

Yao Xue Xue Bao 41(11) , 1090-3, (2006)

To develop the chemical characteristics of Panax notoginseng in order to control its quality.The samples was extracted using pressurized liquid extraction (PLE) and analyzed by HPLC-DAD. The data were evaluated using the "similarity evaluation system for chro...

Zhongguo Zhong Yao Za Zhi 31(13) , 1067-9, (2006)

To determine the content of notoginsenoside R1 and ginsenoside Rg1 in Rupixiao tablet by reverse-phase high performance liquid chromatography.A Kromacil C18 column was used with a mixture of acetonitrile and 0.05% phosphoric acid solution (20:80) as the mobil...

Zhongguo Zhong Xi Yi Jie He Za Zhi 25(8) , 719-22, (2005)

To study the effect drug contained canine serum, prepared by gastric perfusion with Sanchi extract (SE), in inhibiting proliferation and promoting apoptosis of cultured precancerous gastric cells by cell culture.The precancerous model cells (MC) used in the e...

J. Agric. Food Chem. 58(9) , 5770-6, (2010)

As a main and characteristic constituent in Radix notoginseng, the fate of notoginsenoside R1 (NGR1) in human is largely unknown. The present study investigated, for the first time, NGR1 metabolism by human intestinal bacteria and liver subcellular fractions,...

Am. J. Physiol. Gastrointest. Liver Physiol. 306(2) , G111-22, (2014)

Intestinal ischemia and reperfusion (I/R) is a clinical problem occurred for diverse causes with high mortality. Prophylaxis and treatment of intestinal I/R remains a challenge for clinicians. The purpose of the present study was to explore the role of Notogi...

J. Pharm. Biomed. Anal. 41(1) , 274-9, (2006)

A HPLC and pressurized liquid extraction (PLE) method was developed for simultaneous determination of nine saponins, including notoginsenoside R1, ginsenoside Rg1, Re, Rf, Rb1, Rc, Rb2, Rb3 and Rd in Panax notoginseng. The analysis was performed on C18 column...

J. Nat. Prod. 70(7) , 1203-6, (2007)

Three 20(S)-protopanaxatriol-type saponins, ginsenoside-Rg1 (1), notoginsenoside-R1 (2), and ginsenoside-Re (3), were transformed by the fungus Absidia coerulea (AS 3.3389). Compound 1 was converted into five metabolites, ginsenoside-Rh4 (4), 3beta,2beta,25-t...