蛋白磷酸酯酶-1(抗原)
蛋白磷酸酯酶-1(抗原)结构式
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常用名 | 蛋白磷酸酯酶-1(抗原) | 英文名 | pp1 |
|---|---|---|---|---|
| CAS号 | 172889-26-8 | 分子量 | 281.356 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 478.8±40.0 °C at 760 mmHg | |
| 分子式 | C16H19N5 | 熔点 | 205-207ºC | |
| MSDS | 中文版 | 闪点 | 243.4±27.3 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression.
J. Cell Biol. 210 , 23-33, (2015) Proteins associated with the centrosome play key roles in mitotic progression in mammalian cells. The activity of Cdk1-opposing phosphatases at the centrosome must be inhibited during early mitosis to prevent premature dephosphorylation of Cdh1-an activator o... |
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p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
J. Biol. Chem. 290 , 28915-31, (2015) Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1. GTP-bound Rac1 ... |
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Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease.
Aging Cell 14 , 878-86, (2015) Toxicity induced by aberrant protein aggregates in Alzheimer's disease (AD) causes synaptic disconnection and concomitant progressive neurodegeneration that eventually impair cognitive function. cAMP-response element-binding protein (CREB) is a transcription ... |
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Diversification of non-visual photopigment parapinopsin in spectral sensitivity for diverse pineal functions.
BMC Biol. 13 , 73, (2015) Recent genome projects of various animals have uncovered an unexpectedly large number of opsin genes, which encode protein moieties of photoreceptor molecules, in most animals. In visual systems, the biological meanings of this diversification are clear; mult... |
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Spinophilin-Targeted Protein Phosphatase-1 Alleviated Inflammatory Pain by Negative Control of MEK/ERK Signaling in Spinal Cord Dorsal Horn of Rats.
J. Neurosci. 35 , 13989-4001, (2015) Protein phosphatase-1 (PP1), anchored by regulatory or targeting proteins at excitatory glutamatergic synapses, controls the phosphorylation of postsynaptic substrates and regulates the neurotransmission and plasticity. Here, we found that spinophilin, an act... |
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Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells.
PLoS ONE 10 , e0131464, (2015) mTOR inhibitors are used to treat metastatic renal cell cancer (RCC), but most patients eventually become resistant. One possible mechanism for resistance is upregulation of autophagy, a pathway that helps recycle intracellular proteins and promotes cell surv... |
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The molecular basis for development of proinflammatory autoantibodies to progranulin.
J. Autoimmun. 61 , 17-28, (2015) Recently we identified in a wide spectrum of autoimmune diseases frequently occurring proinflammatory autoantibodies directed against progranulin, a direct inhibitor of TNFR1 & 2 and of DR3. In the present study we investigated the mechanisms for the breakdow... |
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Roles of Serine/Threonine Phosphatases in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier.
J. Mol. Neurosci. 57 , 11-20, (2015) Previous studies have demonstrated that low-dose endothelial monocyte-activating polypeptide-II (EMAP-II) induces blood-tumor barrier (BTB) opening via RhoA/Rho kinase/PKC-α/β signaling pathway. In a recent study, we revealed that low-dose EMAP-II induced sig... |
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Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.
Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G703-15, (2015) Inappropriate activation of pattern recognition receptors has been described as a potential trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated the activity and expression of Na(+)/H(+) exchanger (NHE) subtypes in T84 i... |
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The small chemical enzyme inhibitor 5-phenylnicotinic acid/CD13 inhibits cell migration and invasion of tartrate-resistant acid phosphatase/ACP5-overexpressing MDA-MB-231 breast cancer cells.
Exp. Cell Res. 339 , 154-62, (2015) Tartrate-resistant acid phosphatase (TRAP/ACP5/uteroferrin/purple acid phosphatase/PP5) has received considerable attention as a newly discovered proinvasion metastasis driver associated with different malignancies. This renders TRAP an interesting target for... |