离子霉素
离子霉素结构式
|
常用名 | 离子霉素 | 英文名 | Ionomycin |
|---|---|---|---|---|
| CAS号 | 56092-81-0 | 分子量 | 709.00500 | |
| 密度 | 1.072 g/cm3 | 沸点 | 817.2ºC at 760 mmHg | |
| 分子式 | C41H72O9 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 235.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.
Am. J. Physiol. Endocrinol. Metab. 307(2) , E209-24, (2014) Elevating cytosolic Ca(2+) stimulates glucose uptake in skeletal muscle, but how Ca(2+) affects intracellular traffic of GLUT4 is unknown. In tissue, changes in Ca(2+) leading to contraction preclude analysis of the impact of individual, Ca(2+)-derived signal... |
|
|
Regulation of T cell priming by lymphoid stroma.
PLoS ONE 6(11) , e26138, (2011) The priming of immune T cells by their interaction with dendritic cells (DCs) in lymph nodes (LN), one of the early events in productive adaptive immune responses, occurs on a scaffold of lymphoid stromal cells, which have largely been seen as support cells o... |
|
|
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood.
J. Exp. Med. 206(5) , 1009-17, (2009) Two subsets of natural and adaptive regulatory T (T reg) cells have been described, but the identity of adaptive type 1 regulatory (Tr1)-like cells in humans is unclear. We analyzed a subset of human blood CD4(+) T cells--CD45RA(-)CD25(-)interleukin (IL)-7 re... |
|
|
Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.
Biochim. Biophys. Acta 1838(10) , 2607-14, (2014) A diminution in the order of membrane lipids, which occurs during apoptosis, has been shown to correlate with increased membrane susceptibility to hydrolysis by secretory phospholipase A2. Studies with artificial membranes, however, have demonstrated that the... |
|
|
Acute and chronic effects of botulinum neurotoxin a on the mammalian neuromuscular junction.
Muscle Nerve 50(2) , 206-15, (2014) Botulinum neurotoxin A (BoNT/A) cleaves SNAP-25 and inhibits acetylcholine (ACh) release at the neuromuscular junctions (NMJ) to cause neuroparalysis. Previous reports indicate a dyssynchrony between the inhibitory effect of BoNT/A on ACh release and SNAP-25 ... |
|
|
Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults.
PLoS ONE 6(9) , e25610, (2011) Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased ris... |
|
|
High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo.
J. Infect. Dis. 203(10) , 1378-87, (2011) Parvovirus 4 (PARV4) is a recently identified human virus that has been found in livers of patients infected with hepatitis C virus (HCV) and in bone marrow of individuals infected with human immunodeficiency virus (HIV). T cells are important in controlling ... |
|
|
Insufficient secretion of IL-10 by Tregs compromised its control on over-activated CD4+ T effector cells in newly diagnosed adult immune thrombocytopenia patients.
Immunol. Res. 61(3) , 269-80, (2015) Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder. Excessive activated CD4(+) T effector cells (Teffs) and compromised regulatory T cells (Tregs) were reported in ITP patients, yet little is known about the mechanisms. Interleukin-... |
|
|
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.
Nat. Med. 20(4) , 425-9, (2014) HIV-1 persists in a latent reservoir despite antiretroviral therapy (ART). This reservoir is the major barrier to HIV-1 eradication. Current approaches to purging the latent reservoir involve pharmacologic induction of HIV-1 transcription and subsequent killi... |
|
|
Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.
Mol. Cell. Biol. 33(1) , 136-45, (2013) Phospholipase D (PLD), which produces the lipid messenger phosphatidic acid (PA), has been implicated in superoxide generation and degranulation in neutrophils. The basis for this conclusion is the observation that primary alcohols, which interfere with PLD-c... |