Syk抑制剂IV,BAY 61-3606 HCl

更新时间：2025-08-25 18:30:50

Syk抑制剂IV,BAY 61-3606 HCl用途

BAY 61-3606是高活性ATP竞争性,可逆的Syk选择性抑制剂,Ki为7.5 nM,对Btk,Fyn,Itk,Lyn和Src无抑制性。

中文名	2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺
英文名	2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
英文别名	更多

描述	BAY 61-3606是高活性ATP竞争性,可逆的Syk选择性抑制剂,Ki为7.5 nM,对Btk,Fyn,Itk,Lyn和Src无抑制性。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> SYK 研究领域 >> 炎症/免疫
参考文献	[1]. Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2 [2]. Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343.

描述

BAY 61-3606是高活性ATP竞争性,可逆的Syk选择性抑制剂,Ki为7.5 nM,对Btk,Fyn,Itk,Lyn和Src无抑制性。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> SYK

研究领域 >> 炎症/免疫

参考文献

密度	1.4±0.1 g/cm3
分子式	C₂₀H₁₈N₆O₃
分子量	390.395
精确质量	390.144043
PSA	116.66000
LogP	1.75
InChIKey	JWQOJVOKBAAAAR-UHFFFAOYSA-N
SMILES	COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC
折射率	1.696
储存条件	2-8℃

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2-{[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}nicotinamide

cc-526

Kinome_3125

BAY 61-3606

2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide

BAY-61-3606 free base

UNII-61G8S0H9KX

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