毒理学数据:
1、急性毒性：LD50：1700-1970mg/Kg（大白鼠经口）；小鼠经口LC501040mg/kg
2、接触皮肤能引起皮炎，形成过敏症，溅到皮肤和衣服上后应立即用水冲掉。操作人员应穿戴防护用具。
生态学数据:
对水体有一定危害。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GO7875000
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CHEMICAL NAME :
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p-Cresol, 2,6-di-tert-butyl-
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CAS REGISTRY NUMBER :
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128-37-0
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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79
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MOLECULAR FORMULA :
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C15-H24-O
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MOLECULAR WEIGHT :
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220.39
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WISWESSER LINE NOTATION :
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1X1&1&R BQ E1 CX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Human
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
-
Administration into the eye
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SPECIES OBSERVED :
-
Rodent - rabbit
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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80 mg/kg
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TOXIC EFFECTS :
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Behavioral - coma Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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890 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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650 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Lungs, Thorax, or Respiration - chronic pulmonary edema
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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138 mg/kg
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - other changes Blood - hemorrhage
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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180 mg/kg
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TOXIC EFFECTS :
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Behavioral - sleep
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
-
940 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
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DOSE/DURATION :
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2100 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
-
10700 mg/kg
-
TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
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109 gm/kg/2Y-C
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TOXIC EFFECTS :
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Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
27 gm/kg/90D-C
-
TOXIC EFFECTS :
-
Liver - changes in liver weight Endocrine - evidence of thyroid hyperfunction Endocrine - changes in thyroid weight
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
37800 mg/kg/6W-C
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TOXIC EFFECTS :
-
Liver - changes in liver weight Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
5600 mg/kg/16W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
275 mg/kg/26W-C
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TOXIC EFFECTS :
-
Liver - changes in liver weight Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
112 gm/kg/80W-C
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TOXIC EFFECTS :
-
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other proteins
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
5040 mg/kg/7D-C
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TOXIC EFFECTS :
-
Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
13500 mg/kg/18D-I
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TOXIC EFFECTS :
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Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
48600 mg/kg/30D-C
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5 gm/kg/4W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - changes in lung weight Related to Chronic Data - death
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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14 gm/kg/4W-I
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TOXIC EFFECTS :
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Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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1596 mg/kg/14D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
134 gm/kg/32W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - cells (cultured) transformed
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
-
435 mg/kg/69W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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247 gm/kg/3Y-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Liver - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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247 gm/kg/3Y-C
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1423 mg/kg/43W-C
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Liver - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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247 gm/kg
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
963 gm/kg
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TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
6 gm/kg
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SEX/DURATION :
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male 13 week(s) pre-mating female 13 week(s) pre-mating - 3 week(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
18 gm/kg
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SEX/DURATION :
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male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
9 gm/kg
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SEX/DURATION :
-
male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
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TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
35 gm/kg
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SEX/DURATION :
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male 10 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
43800 mg/kg
-
SEX/DURATION :
-
female 52 day(s) pre-mating female 1-21 day(s) after conception
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TOXIC EFFECTS :
-
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
12600 mg/kg
-
SEX/DURATION :
-
female 1-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
1200 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
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TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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TYPE OF TEST :
-
DNA damage
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Dominant lethal test
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
DNA inhibition
-
TYPE OF TEST :
-
Dominant lethal test
-
TYPE OF TEST :
-
Sperm Morphology
MUTATION DATA
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TEST SYSTEM :
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Rodent - hamster Ovary
-
REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 345,73,1995 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,161,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,161,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,6-DI-t-BUTYL-p-CRESOL-air:10H TWA 10 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83383 No. of Facilities: 1526 (estimated) No. of Industries: 32 No. of Occupations: 39 No. of Employees: 28860 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83383 No. of Facilities: 27242 (estimated) No. of Industries: 210 No. of Occupations: 154 No. of Employees: 591238 (estimated) No. of Female Employees: 163774 (estimated)
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