112246-15-8

• 常用中文名：20(R)-人参皂苷Rh2
• 常用英文名：20(R)-Ginsenoside Rh2
• CAS号：112246-15-8
• 分子式：C₃₆H₆₂O₈
• 分子量：622.873
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2018-08-04 12:38:46
• 更新时间：2026-07-02 07:26:18
• 20(R)-Ginsenoside Rh2,基质金属蛋白酶 (MMP) 抑制剂,作为细胞抗增殖剂。它通过阻断细胞增殖和引起 G1 期阻滞而具有抗癌作用。20(R)-Ginsenoside Rh2 诱导细胞凋亡并具有抗炎和抗氧化活性。

名称

• 中文名: R-人参皂苷 Rh2
• 英文名: ginsenoside Rh2
• 中文别名: R-人参皂苷RH2; (R型)人参皂苷Rh2; (20R)Ginsenoside Rh2 (20R)人参皂苷 Rh2，S9036; 20(R)-人参皂苷RH2,10 MM DMSO 溶液; 20(R)-人参皂苷 Rh2; (R型)人参皂苷RH2、20(R)-人参皂苷RH2; 20(R)-人参皂苷RH2标准品; 20(SR)-人参皂苷RH2; 20(R)-人参皂苷 RH2|||(20R)GINSENOSIDE RH2|||GINSENOSIDE RH2|||20(R)-人参皂苷RH2; (20R)Ginsenoside Rh2 (20R)人参皂苷 Rh2,S9036; (R型)人参皂苷Rh2Ginsenoside Rh2; 20(R)GINSENOSIDE RH2 (R型)人参皂苷RH2; 20(R)-Ginsenoside Rh220(R)-人参皂苷Rh2; 人参皂苷R-RH2(R型人参皂苷RH2); 20(R)-人参皂苷RH2对照品; 20(R)-人参皂甙RH2; (R型)人参皂苷RH2,对照品; (R型)人参皂甙RH2; 人参皂苷 R-RH2
• 英文别名: b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydamm-24-en-3-yl; (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl β-D-glucopyranoside; 20(R)-Rh2; 20(SR)-Ginsenoside Rh2; (2R,3R,4S,5R,6R)-2-[[(10S,12S,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6 -methyl-ht-5-en-2-yl]-4,4,10,14,17-pentamethyl-2,3,5,6,7,8,9,11,12,1 3,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxyme thyl)oxane-3,4,5-triol; Ginsenoside-Rh2; (20R)Ginsenoside Rh2|||Ginsenoside Rh2; (3beta,12beta,20R)-12,20-Dihydroxydamm-24-en-3-yl beta-D-glucopyranoside; 20R-Ginsenoside Rh2 //BP; GINSENOSIDE Rh2 (R-FORM); (20R)-12beta,20-Dihydroxydamm-24-en-3beta-yl beta-D-Glucopyranoside; Ginsenoside Rh2, 20(R); 20(R)-Ginsenoside-Rh2; 20(R)-Ginsenoside Rh2, 10 mM in DMSO; b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl; (R) Ginsenoside Rh2; (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside; β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydamm-24-en-3-yl; 20-(R)-Ginsenoside Rh2; β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl; 20(R)-GINSENOSIDERH2; (R-type) ginsenoside Rh2

物化性质

• 密度: 1.19
• 沸点: 726.4±60.0 °C at 760 mmHg
• 熔点: 225 °C
• 分子式: C₃₆H₆₂O₈
• 分子量: 622.873
• 闪点: 393.1±32.9 °C
• 精确质量: 622.444458
• PSA: 139.84000
• LogP: 5.62
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±5.4 mmHg at 25°C
• 折射率: 1.572
• 储存条件: 0-10°C;存放于惰性气体之中;避免湿气 (分解),加热

生物活性

• 描述: 20(R)-Ginsenoside Rh2,基质金属蛋白酶 (MMP) 抑制剂,作为细胞抗增殖剂。它通过阻断细胞增殖和引起 G1 期阻滞而具有抗癌作用。20(R)-Ginsenoside Rh2 诱导细胞凋亡并具有抗炎和抗氧化活性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> MMP
• 参考文献:

  [1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6.

  [2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40.

  [3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.

合成路线

127750-93-0 ~% 112246-15-8

文献：Atopkina, Lyubov N.; Uvarova, Nina I.; Elyakov, Georgi B. Carbohydrate Research, 1997 ,  vol. 303,  # 4  p. 449 - 451

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