20(R)-人参皂苷Rh2

• 常用名: 20(R)-人参皂苷Rh2
• 英文名: 20(R)-Ginsenoside Rh2
• CAS号: 112246-15-8
• 分子量: 622.873
• 密度: 1.19
• 沸点: 726.4±60.0 °C at 760 mmHg
• 分子式: C₃₆H₆₂O₈
• 熔点: 225 °C
• 闪点: 393.1±32.9 °C

20(R)-人参皂苷Rh2用途

20(R)-Ginsenoside Rh2,基质金属蛋白酶 (MMP) 抑制剂,作为细胞抗增殖剂。它通过阻断细胞增殖和引起 G1 期阻滞而具有抗癌作用。20(R)-Ginsenoside Rh2 诱导细胞凋亡并具有抗炎和抗氧化活性。

20(R)-人参皂苷Rh2名称

• 中文名: R-人参皂苷 Rh2
• 英文名: ginsenoside Rh2
• 中文别名: (R型)人参皂甙RH2 | (R型)人参皂苷Rh2 | 20(R)-人参皂苷 Rh2

20(R)-人参皂苷Rh2生物活性

• 描述: 20(R)-Ginsenoside Rh2,基质金属蛋白酶 (MMP) 抑制剂,作为细胞抗增殖剂。它通过阻断细胞增殖和引起 G1 期阻滞而具有抗癌作用。20(R)-Ginsenoside Rh2 诱导细胞凋亡并具有抗炎和抗氧化活性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> MMP
• 参考文献:

  [1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6.

  [2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40.

  [3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.

20(R)-人参皂苷Rh2物理化学性质

• 密度: 1.19
• 沸点: 726.4±60.0 °C at 760 mmHg
• 熔点: 225 °C
• 分子式: C₃₆H₆₂O₈
• 分子量: 622.873
• 闪点: 393.1±32.9 °C
• 精确质量: 622.444458
• PSA: 139.84000
• LogP: 5.62
• InChIKey: CKUVNOCSBYYHIS-FJSBSAJOSA-N
• SMILES: CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC1C3(C)CCC(OC4OC(CO)C(O)C(O)C4O)C(C)(C)C3CCC12C
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±5.4 mmHg at 25°C
• 折射率: 1.572
• 储存条件: 0-10°C;存放于惰性气体之中;避免湿气 (分解),加热

20(R)-人参皂苷Rh2靶点实验

查看更多实验

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实验名称：Fluorescence Mpro inhibition assay (S1) from Article : "Open science discovery of pot... 来源：BindingDB 靶标：N/A External Id：BindingDB_11549_3

实验名称：Toxicity in RANKL and TNFalpha-pretreated mouse RAW264 cells assessed as effect on ce... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1787375

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20(R)-人参皂苷Rh2英文别名

• (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl β-D-glucopyranoside
• 20(R)-Ginsenoside Rh2
• 20(R)-Ginsenoside-Rh2
• b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl
• Ginsenoside-Rh2
• (R) Ginsenoside Rh2
• (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside
• 20-(R)-Ginsenoside Rh2
• β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl
• 20(R)-GINSENOSIDERH2