1330052-59-9

• 常用中文名：Ethacrynic acid D5
• 常用英文名：Ethacrynic acid D5
• CAS号：1330052-59-9
• 分子式：C₁₃H₇D₅Cl₂O₄
• 分子量：308.169
• 相关类别： 信号通路 跨膜转运 钙通道
• 发布时间：2018-06-16 06:26:58
• 更新时间：2026-07-01 13:15:43
• Ethacrynic acid D5 是 Ethacrynic acid 的氘代物。Ethacrynic acid 是一种利尿剂。Ethacrynic acid 是谷胱甘肽 S-转移酶 (GSTs) 的抑制剂。Ethacrynic acid 是 NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。Ethacrynic acid 还抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。Ethacrynic acid 具有抗炎特性,可减轻类维生素A诱导的小鼠耳部水肿。

名称

• 中文名: 氘5-依他克酸
• 英文名: {2,3-Dichloro-4-[2-methylene(2H5)butanoyl]phenoxy}acetic acid
• 中文别名: [2H5]-依他尼酸; 利尿酸-D5; [2H5]-乙烯丙酸; 乙酸-D5
• 英文别名: Mingit-d5; Edecrina-d5; NSC 85791-d5; Etacrynic Acid-d5; Ethacrynic Impurity 1; [2H5]-Ethacrynic acid; Edecrin-d5; Edecril-d5; MK 595-d5; D5-Ethacrynic acid; Crinuril-d5; NSC 624008-d5; Ethacrynic acid D5Q: What is Ethacrynic acid D5 Q: What is the CAS Number of Ethacrynic acid D5 Q: What is the storage condition of Ethacrynic acid D5 Q: What e the applications of Ethacrynic acid D5; Uregit-d5; Ethacrynic Acid-d5; 2-[2,3-dichloro-4-(3,3,4,4,4-pentadeuterio-2-methylidenebutanoyl)phenoxy]acetic acid; HydroMedin-d5; Endecril-d5; Taladren-d5; [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy-d5]acetic Acid; 2-[2,3-Dichloro-4-(2-methylene(4,4,4,3,3-d5)butanoyl)phenoxy]acetic acid; Etakrinic Acid-d5; 2-[2,3-Dichloro-4-(2-Methylene-1-oxobutyl)phenoxy-d5]acetic Acid; HidroMedin-d5; Otacril-d5; ReoMax-d5

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 480.0±45.0 °C at 760 mmHg
• 分子式: C₁₃H₇D₅Cl₂O₄
• 分子量: 308.169
• 闪点: 244.1±28.7 °C
• 精确质量: 307.042633
• LogP: 3.36
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.559
• 储存条件: -20°C，干燥，密封

生物活性

• 描述: Ethacrynic acid D5 是 Ethacrynic acid 的氘代物。Ethacrynic acid 是一种利尿剂。Ethacrynic acid 是谷胱甘肽 S-转移酶 (GSTs) 的抑制剂。Ethacrynic acid 是 NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。Ethacrynic acid 还抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。Ethacrynic acid 具有抗炎特性,可减轻类维生素A诱导的小鼠耳部水肿。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 代谢酶/蛋白酶 >> 谷胱甘肽S-转移酶
  研究领域 >> 炎症/免疫
• 靶点:

  Glutathione S-transferases (GSTs)[1]; NF-κB-signaling pathway[2]; L-type voltage-dependent and store-operated calcium channel[3]

• 参考文献:

  [1]. Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256.

  [2]. Harada T, et al. Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. Clinics (Sao Paulo). 2018 Oct 18;73:e332.

  [3]. Zhao XX, et al. Ethacrynic acid inhibits airway smooth muscle contraction in mice. Sheng Li Xue Bao. 2019 Dec 25;71(6):863-873.

  [4]. Byun HJ, et al. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. Biomol Ther (Seoul). 2013 Sep 30;21(5):338-42.

安全

• 危害码 (欧洲): Xi