13739-02-1

• 常用中文名：双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸
• 常用英文名：Diacerein
• CAS号：13739-02-1
• 分子式：C₁₉H₁₂O₈
• 分子量：368.294
• 相关类别： 原料药 影响免疫功能药 免疫抑制药
• 发布时间：2018-05-12 08:00:00
• 更新时间：2026-07-01 00:41:17
• Diacerein是白介素-1β抑制剂,是慢效的蒽醌类化合物。

名称

• 中文名: 1,8-二乙酰基-3-羧基蒽醌
• 英文名: 1,8-Diacetoxy-3-carboxyanthraquinone
• 中文别名: 双醋瑞因,10 MM DMSO 溶液; 双乙酰基大黄酸; 4,5-二乙酰氧基-9,10-二氧代-9,10-二氢蒽-2-甲酸; 蒜素/大蒜辣素; 安必丁; 达赛瑞英; 双醋瑞因; 4,5-二乙酰氧基蒽醌-2-羧酸; 二乙酰大黄酸; DIACEREIN 双醋瑞因 标准品; 双醋瑞因标准品; 二乙酰基大黄酸; 双醋瑞因 标准品; 狄氏菌杂质; 双醋瑞因对照品; 天然双醋瑞因粉末; 双乙酰大黄酸; 4,5-二乙酰-9,10-二氧-2-蒽羧酸; 双醋瑞因;二乙酰大黄酸; 双醋瑞因/双乙酰基大黄酸; Diacerein试剂; 双醋瑞因|||DIACERHEIN|||FISIOD|||DIACETYHEIN; 双醋瑞因 (HPLC); Diacerein (Standd) #天然产物 HY-N0283R; 二乙酰二氢蒽羧酸; 双醋瑞因, Diacerein 其他西药原料; 双醋瑞因DIACEREIN; 双醋瑞因 13-1; DIACEREIN 双醋瑞因; 双醋瑞因,达赛瑞英,安必丁; 黑蒜提取物,黑蒜粉; 双醋瑞因杂质混合物 标准品; 4,5-二乙酰氧基-9,10-二氧代-9,10-二氢蒽-2-羧酸
• 英文别名: MFCD00468030; Fisiodar; 4,5-diacetoxy-9,10-diketo-anthracene-2-cboxylic acid; Diacerein, 10 mM in DMSO; EINECS 237-310-2; Diacerein>; Diacerein //BP; 4,5-diacetyhein; 4,5-diacetyloxy-9,10-dioxo-2-anthracenecboxylic acid; Diacerein for thritis Treatment; 4,5-diacetyloxy-9,10-dioxo-anthracene-2-cboxylic acid; DIACETYL RHEIN(P); Diacerein (1,8-Diacetoxy-3-cboxyanthraquinone); 4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthracenecboxylic acid; Diacerein(Y0001595); Diacerein, （HPLC); 1,8-DIACETOXY-3-CBOXYANTHRAQUINONE; Rhein Diacetate; Diacerein API; 9,10-dihydro-4,5-diacetoxy-9,-anthracenecboxylicacid; 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecboxylic Acid; Diacerein (Diacerhein); 4,5-Diacetoxyanthraquinone-2-carboxylic Acid; 1,8-diacetoxyanthraquinone-3-cboxylicacid; diacetylrhein; ICN-17261; 4,5-Diacetoxy-9,10-dioxo-2-anthracenecboxylic acid; 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-cboxylic acid; 4,5-diacetylrhein; DIACEREIN; Diacerein IP; ICN17261; 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; SF 277; Diacerein - Bio-X; Diacetine; 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicacidiacetate; 4,5-diacetyloxy-9,10-dioxoanthracene-2-cboxylic acid; 4,5-Diacetoxyanthraquinone-2-cboxylic Acid; 4,5-Diacetoxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid; DIACERHEIN; DIACETYL RHEIN; Diacerein CRS; trod; DIACERHEIN;DIACETYHEIN;FISIOD;TROD; 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecboxylicaci; 4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecboxylic acid; Diacerhein|||Fisiod|||Diacetyhein; 2-Anthracenecboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo; Diacerein impurity mixture CRS; rhein,diacetate; 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid; artrodar; Diacereine; DiacereinQ: What is Diacerein Q: What is the CAS Number of Diacerein Q: What is the storage condition of Diacerein Q: What e the applications of Diacerein; DAR; 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaciddiacetate; Fisiod; Diacerein 13-1

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 631.5±55.0 °C at 760 mmHg
• 熔点: 217-2180C
• 分子式: C₁₉H₁₂O₈
• 分子量: 368.294
• 闪点: 231.8±25.0 °C
• 精确质量: 368.053223
• PSA: 124.04000
• LogP: 1.99
• 外观性状: 固体;Light yellow to Amber to Dark green powder to crystal
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.634
• 储存条件: Refrigerator

生物活性

• 描述: Diacerein是白介素-1β抑制剂,是慢效的蒽醌类化合物。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
  天然产物 >> 醌类
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/Diacerein

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CB8781000 CHEMICAL NAME : 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, diacetate CAS REGISTRY NUMBER : 13739-02-1 BEILSTEIN REFERENCE NO. : 2184909 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C19-H12-O8 MOLECULAR WEIGHT : 368.31 WISWESSER LINE NOTATION : L C666 BV IVJ DOV1 FVQ NOV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,445,1979

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: CB8781000
• 海关编码: 2918990090

合成路线

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海关

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%