521-52-8

• 常用中文名：吴耳酸
• 常用英文名：Vulpic acid
• CAS号：521-52-8
• 分子式：C₁₉H₁₄O₅
• 分子量：322.31
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-06-08 20:24:53
• 更新时间：2026-07-01 22:49:06
• Vulpinic acid是一种地衣代谢物,可减少H2O2诱导的人脐静脉内皮细胞(HUVEC)活性氧生成、氧化应激和氧化应激相关损伤。外阴酸对葡萄球菌、肠球菌和厌氧菌有活性。外阴酸具有动脉粥样硬化研究的潜力[1][2]。

名称

• 中文名: 吴耳酸
• 英文名: Vulpinic Acid
• 中文别名: 3,4-二羟基-2,5-二苯基-2,4-已二稀二酸甲酯-3,6-内酯; 狐衣酸; 枕酸甲酯; 狐衣酸,10 MM DMSO 溶液
• 英文别名: VULPIC ACID; Phenyl[(2E)-3-hydroxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene]acetic acid methyl ester; staphylococci,Reactive Oxygen Species,inhibit,Lichen,enterococci,Inhibitor,Endogenous Metabolite,metabolite,H2O2,anaerobic bacteria,atherosclerosis,Vulpinic Acid,HUVEC,oxidative stress,Bacterial; [(2E)-3-Hydroxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene]phenylacetic acid methyl ester; vulpinic acid; Benzeneacetic acid, α-(3-hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)-, methyl ester, (αE); 3,4-DIHYDROXY-2,5-DIPHENYL-2,4-HEXA-DIENEDIOIC ACID METHYL ESTER 3,6-LACTONE; α-[(2E)-3-Hydroxy-5-oxo-4-phenylfuran-2(5H)-ylidene]benzeneacetic acid methyl ester; VULPINIC ACID; VULPINIC ACID(P); (3-hydroxy-5-oxo-4-phenyl-2(5h)-furylidene)phenyl-aceticacimethylester; 2,4-hexadienedioicacid,3,4-dihydroxy-2,5-diphenyl-,mono-gamma-lactone,met; PULVINIC ACID METHYL ESTER; methyl (E)-2-(3-hydroxy-5-oxo-4-phenylfuran-2(5H)-ylidene)-2-phenylacetate; (αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid methyl ester; methyl 2-(3,5-dioxo-4-phenyl-2-furylidene)-2-phenylacetate; Vulpinic Acid, 10 mM in DMSO; alpha)-furanaceticacid,3-hydroxy-5-oxo-alpha,4-diphenyl-delta(sup2(5hmet; (aE)-a-(3-Hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)benzeneacetic Acid Methyl Ester; methyl (2E)-(3-hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)(phenyl)ethanoate

物化性质

• 密度: 1.375g/cm3
• 沸点: 568.8ºC at 760mmHg
• 熔点: 146-148ºC
• 分子式: C₁₉H₁₄O₅
• 分子量: 322.31
• 闪点: 210.2ºC
• 精确质量: 322.08400
• PSA: 72.83000
• LogP: 3.09680
• 折射率: 1.656
• 储存条件: -20°C Freezer

生物活性

• 描述: Vulpinic acid是一种地衣代谢物,可减少H2O2诱导的人脐静脉内皮细胞(HUVEC)活性氧生成、氧化应激和氧化应激相关损伤。外阴酸对葡萄球菌、肠球菌和厌氧菌有活性。外阴酸具有动脉粥样硬化研究的潜力[1][2]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. E Sahin, et al. Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. Hum Exp Toxicol. 2019 Jun;38(6):675-684.

  [2]. M Lauterwein, et al. In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms. Antimicrob Agents Chemother. 1995 Nov;39(11):2541-3.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HF3500000 CHEMICAL NAME : Delta(sup 2(5H),alpha)-furanacetic acid, 3-hydroxy-5-oxo-alpha,4-diphenyl-, methyl ester CAS REGISTRY NUMBER : 521-52-8 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C19-H14-O5 MOLECULAR WEIGHT : 322.33 WISWESSER LINE NOTATION : T5VOYJ CUYR&VO1 DQ ER HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,30,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02804

安全

• 风险声明 (欧洲): 28
• 安全声明 (欧洲): 1-22-45
• 危险品运输编码: UN 3172

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