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24150-24-1

24150-24-1结构式

英文名	meso-tetra-O-methyl nordihydroguaiaretic acid
英文别名	terameprocol tetramethyl Nordihydroguaiaretic Acid Exclusive 4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene tetramethyl Nordihydroguaiaretic Acid Benzene, 4-[(2R,3S)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxy-

描述	Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。
相关类别	研究领域 >> 癌症研究领域 >> 感染信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
参考文献	[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000. [2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7. [3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.