96736-12-8

• 常用中文名：P物质肽[DG1, DPHE5, DTRP7, 9, LEU11] SUBSTANCE P
• 常用英文名：(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P
• CAS号：96736-12-8
• 分子式：C₇₉H₁₀₉N₁₉O₁₂
• 分子量：1516.831
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 Bombesin Receptor
• 发布时间：2017-11-30 10:14:51
• 更新时间：2026-07-04 15:27:18
• [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 是 P 物质的衍生物,是神经肽和趋化因子受体的偏向激动剂。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 激活 G12。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 与 IL-8 和 GRP受体 结合。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 抑制 ERK-2 激活,激活 JNK 活性。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 刺激中性粒细胞迁移和 Ca2+ 动员增加。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 也是一种 bombesin 拮抗剂,并抑制小细胞肺癌的生长。

名称

• 中文名: P物质肽[DG1, DPHE5, DTRP7, 9, LEU11] SUBSTANCE P
• 英文名: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
• 中文别名: 化合物:(D-g1,D-Phe,D-Trp·,Leu11)-Substance P; 化合物：(D-g1,D-Phe,D-Trp·,Leu11)-Substance P; 物质P H-D-G-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2; D-精氨酸1,D-苯丙氨酸5,D-色氨酸7,9,亮氨酸11]P物质
• 英文别名: (D-g1,D-Phe5,D-Trp7; [D-G1, D-PHE5, D-TRP7,9, LEU11]-SUBSTANCE P; Substance P, [D-g1, D-Phe5, D-Trp7,9, Leu11]; D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2; (D-g,D-Phe,D-Trp·,Leu)-Substance P; D-G-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2; H-D-G-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2; D-g-L-Pro-L-Lys-L-Pro-D-Phe-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2; substance P, Phe(5)-Trp(7,9)-Leu; DG-PRO-LYS-PRO-DPHE-GLN-DTRP-PHE-DTRP-LEU-LEU-NH2: DA-PKP-DF-Q-DW-F-DW-LL-NH2; (D-g1,D-Phe5,D-Trp7·9,Leu11)-Substance P H-D-g-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; AntagonistD,D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; Substance P-[D-Arg1,D-Phe5,D-Trp7,9,Leu11]; D-Arg-L-Pro-L-Lys-L-Pro-D-Phe-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2; D-g-L-Pro-L-Lys-L-Pro-D-Phe-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2; M.W. 1516.85 C79H109N19O12; C79H109N19O12; Antagonist D; D-g1,D-Phe5,D-Trp; D-Arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide; L-Leucinamide, D-ginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl; AntagonistD, D-g-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; DARG-PRO-LYS-PRO-DPHE-GLN-DTRP-PHE-DTRP-LEU-LEU-NH2: DA-PKP-DF-Q-DW-F-DW-LL-NH2; H-D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₇₉H₁₀₉N₁₉O₁₂
• 分子量: 1516.831
• 精确质量: 1515.850342
• PSA: 505.12000
• LogP: 3.94
• 折射率: 1.677

生物活性

• 描述: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 是 P 物质的衍生物,是神经肽和趋化因子受体的偏向激动剂。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 激活 G12。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 与 IL-8 和 GRP受体 结合。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 抑制 ERK-2 激活,激活 JNK 活性。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 刺激中性粒细胞迁移和 Ca2+ 动员增加。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 也是一种 bombesin 拮抗剂,并抑制小细胞肺癌的生长。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor
  信号通路 >> MAPK/ERK信号通路 >> JNK
• 参考文献:

  [1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104.

  [2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport