(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P

更新时间：2024-01-02 10:59:49

(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P结构式	常用名	(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P	英文名	(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P
	CAS号	96736-12-8	分子量	1516.831
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₇₉H₁₀₉N₁₉O₁₂	熔点	N/A
	MSDS	美版	闪点	N/A

用途

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 是 P 物质的衍生物,是神经肽和趋化因子受体的偏向激动剂。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 激活 G12。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 与 IL-8 和 GRP受体结合。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 抑制 ERK-2 激活,激活 JNK 活性。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 刺激中性粒细胞迁移和 Ca2+ 动员增加。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 也是一种 bombesin 拮抗剂,并抑制小细胞肺癌的生长。

英文名	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
英文别名	更多

描述	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 是 P 物质的衍生物,是神经肽和趋化因子受体的偏向激动剂。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 激活 G12。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 与 IL-8 和 GRP受体结合。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 抑制 ERK-2 激活,激活 JNK 活性。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 刺激中性粒细胞迁移和 Ca2+ 动员增加。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 也是一种 bombesin 拮抗剂,并抑制小细胞肺癌的生长。
相关类别	研究领域 >> 癌症信号通路 >> 免疫及炎症 >> 白细胞介素相关研究领域 >> 炎症/免疫信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor 信号通路 >> MAPK/ERK信号通路 >> JNK
参考文献	[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104. [2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63.

描述

相关类别

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor

信号通路 >> MAPK/ERK信号通路 >> JNK

参考文献

[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104.

[2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63.

密度	1.4±0.1 g/cm3
分子式	C₇₉H₁₀₉N₁₉O₁₂
分子量	1516.831
精确质量	1515.850342
PSA	505.12000
LogP	3.94
折射率	1.677

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

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AntagonistD,D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2

L-Leucinamide, D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-

D-Arg-L-Pro-L-Lys-L-Pro-D-Phe-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2

M.W. 1516.85 C79H109N19O12

D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2

D-Arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide

H-D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2

DARG-PRO-LYS-PRO-DPHE-GLN-DTRP-PHE-DTRP-LEU-LEU-NH2: DA-PKP-DF-Q-DW-F-DW-LL-NH2

Substance P-[D-Arg1,D-Phe5,D-Trp7,9,Leu11]

上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

吉尔生化（上海）有限公司
上海市上海市闵行区
产品名：Substance P
纯度：98.0%
规格：1g
联系人：杨经理
联系电话：13641803416

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
产品网址：http://www.aladdin-e.com/zh_cn/D287882.html
纯度：98.0%
规格：1mg/1g/1g/1g
联系人：阿拉丁
联系电话：400-620-6333

福州飞净生物科技有限公司
福建省福州市闽侯县
产品名：P物质肽[DArg1, DPhe5, DTrp7, 9, Leu11] Substance P
纯度：98.0%
规格：5mg/10mg/50mg/100mg
联系人：小飞
联系电话：18059081430

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(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P

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