56293-29-9

• 常用中文名：苦豆碱
• 常用英文名：Aloperine
• CAS号：56293-29-9
• 分子式：C₁₅H₂₄N₂
• 分子量：232.365
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-07-22 04:37:38
• 更新时间：2024-01-01 18:54:42
• Aloperine 是一种在苦参类 (例如苦豆子 Sophora alopecuroides L) 植物中生物碱,其具有抗癌,抗炎和抗病毒特性。Aloperine 被广泛用于治疗过敏性接触性皮炎湿疹和其他皮肤炎症。Aloperine 诱导 HL-60 细胞中诱导凋亡 apoptosis 和自噬 autophagy。

名称

• 中文名: 苦豆碱
• 英文名: aloperine
• 英文别名: ALOPERIN; ALLOPTERIN; Aloperine,orMosanine; (1R,2S,9R,10R)-3,15-Diazatetracyclo[7.7.1.0.0]heptadec-7-ene; 6,13-Methano-2H-dipyrido[1,2-a:3',2'-e]azocine, 1,3,4,6,6a,7,8,9,10,12,13,13a-dodecahydro-, (6R,6aR,13R,13aS)-

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 367.7±37.0 °C at 760 mmHg
• 熔点: 69 - 71ºC
• 分子式: C₁₅H₂₄N₂
• 分子量: 232.365
• 闪点: 155.8±17.5 °C
• 精确质量: 232.193954
• PSA: 15.27000
• LogP: 3.21
• 外观性状: 黄色结晶粉末
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.583
• 储存条件: -20℃

生物活性

• 描述: Aloperine 是一种在苦参类 (例如苦豆子 Sophora alopecuroides L) 植物中生物碱,其具有抗癌,抗炎和抗病毒特性。Aloperine 被广泛用于治疗过敏性接触性皮炎湿疹和其他皮肤炎症。Aloperine 诱导 HL-60 细胞中诱导凋亡 apoptosis 和自噬 autophagy。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 炎症/免疫
• 体外研究: Aloperine(1-20 mM; 24小时)使癌细胞中的生长抑制性IC50值在0.04至1.36 mM之间,HL-60,U937,K562,EC109,A549和HepG2细胞中的IC50值分别为0.04,0.27,0.36,1.11,1.18和1.36 mM[1]。Aloperine(1-20 mM; 24小时)诱导细胞凋亡并降低HL-60细胞中bcl-2的表达[1]。Aloperine(20-100 mM; 18小时)诱导HL-60细胞中的自噬和酸性液泡的形成[1]。
• 参考文献:

  [1]. Lin Z, et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011 May;108(5):304-9.

  [2]. Yuan XY, et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010 Mar 10;629(1-3):147-52.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RM2979500 CHEMICAL NAME : Ormosanine, 16,17-didehydro-9-de-2-piperidinyl-, (7-alpha,9-alpha)- CAS REGISTRY NUMBER : 56293-29-9 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C15-H24-N2 MOLECULAR WEIGHT : 232.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 480 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 10,360,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 869 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 18,214,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 154 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 17,170,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22
• 危险品运输编码: NONH for all modes of transport
• RTECS号: RM2979500

上下游产品

上游产品  4
220384-56-5 220384-61-2 792937-20-3 792937-19-0
下游产品  0