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| 中文名 | 帕苯达唑 |
|---|---|
| 英文名 | Parbendazole |
| 中文别名 | 丁苯咪唑 |
| 英文别名 |
methyl5-butyl-2-benzimidazolecarbamate
SKandF 29044 TCMDC-131798 Methyl (5-butyl-1H-benzimidazol-2-yl)carbamate Carbamic acid, N-(5-butyl-1H-benzimidazol-2-yl)-, methyl ester EINECS 238-133-3 SK&F 29044 5-butyl-2-benzimidazolecarbamicacimethylester Methyl (5-butyl-1H-benzoimidazol-2-yl)carbamate helmatac pbdz Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate Parbendazole verminum |
| 描述 | Parbendazole 是一种有效的 microtubule 重组抑制剂,能够破坏微管蛋白,EC50 值为 8.79 nM,具有广谱的驱虫作用。 |
|---|---|
| 相关类别 | |
| 靶点 |
EC50: 8.79 nM (tubulin)[1] |
| 体外研究 | Parbendazole是一种微管蛋白去稳定剂,EC50为8.79 nM,可诱导DNA损伤[1]。帕潘哒唑(2-10μM)剂量依赖性地抑制微管组装,IC50为3μM。 Parbendazole(2-20μM)处理的细胞显示Vero细胞中完全没有微管[2]。 Parbendazole(高达10μM)抑制CLd-AX myxamoebae的生长。帕潘哒唑(2-5μM)有效抑制从野生型粘液瘤中纯化的微管蛋白[3]。 |
| 激酶实验 | 纯的微管蛋白通过体外装配和拆卸的2个循环从绵羊脑中获得。在即将使用之前，将蛋白质以130000g离心30分钟以除去任何聚集物。其在0.025M管式缓冲液，0-5mM EGTA，0-25mM Mg 2 SO 4> 0.1mM GTP中以0-2mg / mL的蛋白质浓度使用。使用0.1μM和4μM之间的帕苯达唑浓度和2％（v / v）DMF（二甲基甲酰胺）作为载体，通过平衡透析测定药物结合。通过在26℃下持续搅拌2小时来实现平衡，使用牛血清白蛋白作为标准。在25-200B液体闪烁计数器[2]中，在PCS中计数200μL等分试样。 |
| 细胞实验 | 将来自猴肾的已建立的细胞系Vero细胞接种在补充有10％（v / v）胎牛血清的DMEM中，置于多孔培养皿中的玻璃盖玻片上。使它们沉降，并在37℃的潮湿气氛中铺展2-5小时。此后，将培养基更换为含有2,10或20μM帕苯达唑和1％（v / v）DMSO对照的DMEM，其含有1％（v / v）DMSO或不添加[2]。 |
| 参考文献 |
| 密度 | 1.2±0.1 g/cm3 |
|---|---|
| 熔点 | 255-257°C |
| 分子式 | C13H17N3O2 |
| 分子量 | 247.293 |
| 精确质量 | 247.132080 |
| PSA | 67.01000 |
| LogP | 3.57 |
| 外观性状 | 固体 |
| 折射率 | 1.632 |
| 储存条件 | 库房通风低温干燥 |
| 稳定性 | Stable. Incompatible with strong oxidizing agents. |
| 水溶解性 | <0.1 g/100 mL at 18 ºC |
| 分子结构 | 1、 摩尔折射率：71.45 2、 摩尔体积（m3/mol）：200.3 3、 等张比容（90.2K）：544.4 4、 表面张力（dyne/cm）：54.5 5、 极化率（10-24cm3）：28.32 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:3 4.可旋转化学键数量:5 5.互变异构体数量:5 6.拓扑分子极性表面积67 7.重原子数量:18 8.表面电荷:0 9.复杂度:285 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
| 更多 | 1. 性状：白色晶体状粉末 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：224-227 5. 沸点（ºC,常压）：455 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：3.02 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：不能溶解的 |
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SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Parbendazole REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
CAS-No.: 14255-87-9 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Reproductive toxicity (Category 2), H361 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC Xn HarmfulR22, R63 For the full text of the R-phrases mentioned in this Section, see Section 16. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordWarning Hazard statement(s) H302Harmful if swallowed. H361Suspected of damaging fertility or the unborn child. Precautionary statement(s) P281Use personal protective equipment as required. Supplemental Hazardnone Statements Other hazards - none SECTION 3: Composition/information on ingredients Substances Synonyms: Methyl (5-butyl-1H-benzoimidazol-2-yl)carbamate Methyl 5(6)-butyl-2-benzimidazolecarbamate Formula: C13H17N3O2 Molecular Weight: 247,29 g/mol CAS-No.: 14255-87-9 EC-No.: 238-133-3 Hazardous ingredients according to Regulation (EC) No 1272/2008 ComponentClassificationConcentration Parbendazole Acute Tox. 4; Repr. 2; H302, - H361 Hazardous ingredients according to Directive 1999/45/EC ComponentClassificationConcentration Parbendazole Xn, R22 - R63- For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx) Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C Specific end use(s) A part from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: powder Colour: white b) Odourodourless c) Odour Thresholdno data available d) pHno data available e) Melting point/freezing255 - 257 °C - lit. - Decomposes on heating. point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evapouration rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubility0,01 g/l at 18 °C o) Partition coefficient: n- log Pow: 3,43 octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity LD50 Oral - rat - > 40 mg/kg LD50 Oral - mouse - 1.700 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity Laboratory experiments have shown teratogenic effects. Reproductive toxicity - rat - Oral Effects on Embryo or Fetus: Fetal death. Specific Developmental Abnormalities: Central nervous system. Specific Developmental Abnormalities: Craniofacial (including nose and tongue). Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: DD6495000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. SECTION 12: Ecological information Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects no data available SECTION 13: Disposal considerations Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: -IMDG: -IATA: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA:Not dangerous goods Transport hazard class(es) ADR/RID: -IMDG: -IATA: - Packaging group ADR/RID: -IMDG: -IATA: - Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15: Regulatory information This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment For this product a chemical safety assessment was not carried out SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. Acute Tox.Acute toxicity H302Harmful if swallowed. H361Suspected of damaging fertility or the unborn child. Repr.Reproductive toxicity Full text of R-phrases referred to under sections 2 and 3 XnHarmful R22Harmful if swallowed. R63Possible risk of harm to the unborn child. Further information Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale. |
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CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| 符号 |
GHS07, GHS08 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H361 |
| 警示性声明 | P280-P301 + P312 + P330 |
| 危害码 (欧洲) | Xn |
| 风险声明 (欧洲) | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
| 安全声明 (欧洲) | S26-S36/37/39 |
| 危险品运输编码 | 2811 |
| RTECS号 | DD6495000 |
| 海关编码 | 2933990090 |
| 海关编码 | 2933990090 |
|---|---|
| 中文概述 | 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |