14769-73-4

• 常用中文名：左旋咪唑
• 常用英文名：(S)-(-)-Levamisole
• CAS号：14769-73-4
• 分子式：C₁₁H₁₂N₂S
• 分子量：204.291
• 相关类别： 原料药 抗寄生虫病药 驱肠虫药
• 发布时间：2018-02-07 08:00:00
• 更新时间：2024-01-03 11:03:48
• (S) -(-)-左旋咪唑(左旋咪唑),一种具有免疫调节特性的驱虫剂。(S) -(-)-左旋咪唑是α3β2(EC50=300μM)和α3β4(EC50=100μM)亚型nAChRs的正变构调节剂(PAM)。口服活性[1][2]。

名称

• 中文名: 保松噻
• 英文名: levamisole
• 中文别名: 左旋咪唑; (S)-6-苯基-2,3,5,6-四氢-咪唑[2,1-B]噻唑; 左旋咪唑碱; 左旋-6-苯基-2,3,5,6-四氢咪唑并[2,1-b]噻唑
• 英文别名: MFCD00792481; 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole; Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-; levomysol; L-teramisole; 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole; lepuron; UNII:C8M7RFE4NO; (±)-Tetramisole; dl-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole; 6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole; dl-Tetramisol; LEVAMISOLE BASE; EINECS 238-836-5; Tetramisole; 2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole; Levamisole; Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-; dl-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazole; (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole; (±)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole; Ketrax; dl-Tetramisole; Nilverm base; Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (±)-; tetramizole; l-tetramisole

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 344.4±45.0 °C at 760 mmHg
• 熔点: 230 - 233ºC
• 分子式: C₁₁H₁₂N₂S
• 分子量: 204.291
• 闪点: 162.1±28.7 °C
• 精确质量: 204.072113
• PSA: 40.90000
• LogP: 1.85
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.713
• 储存条件: 0-6°C

生物活性

• 描述: (S) -(-)-左旋咪唑(左旋咪唑),一种具有免疫调节特性的驱虫剂。(S) -(-)-左旋咪唑是α3β2(EC50=300μM)和α3β4(EC50=100μM)亚型nAChRs的正变构调节剂(PAM)。口服活性[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 炎症/免疫
• 体内研究: (S) -(-)-左旋咪唑(左旋咪唑)(50μg/ml和200μg/ml；p.o.；30天)可防止喂食高脂肪饮食的小鼠体重增加[2]。
• 参考文献:

  [1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872.

  [2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ5940000 CHEMICAL NAME : Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)- CAS REGISTRY NUMBER : 14769-73-4 LAST UPDATED : 199512 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C11-H12-N2-S MOLECULAR WEIGHT : 204.31 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 480 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 210 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : Cytogenetic analysis MUTATION DATA TEST SYSTEM : Human DOSE/DURATION : 2142 ug/kg REFERENCE : PTBIAN Pathologie Biologie. (Expansion Scientifique Francaise, 15, rue St. Benoit, F-75278 Paris Cedex 06, France) V.17- 1969- Volume(issue)/page/year: 28,323,1980 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: UN 2811
• 海关编码: 2934999090

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海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%