786593-06-4

• 常用中文名：脱水穿心莲内酯琥珀酸半酯
• 常用英文名：Dehydroandrographolide succinate
• CAS号：786593-06-4
• 分子式：C₂₈H₃₆O₁₀
• 分子量：532.579
• 相关类别： 分析化学 标准品 中药标准品
• 发布时间：2018-05-18 08:00:00
• 更新时间：2026-07-02 09:59:13
• Dehydroandrographolide succinate,从中药穿心莲中提取,因其具有免疫刺激、抗感染和抗炎作用,被广泛应用于病毒性肺炎和病毒性上呼吸道感染的治疗。

名称

• 中文名: 脱水穿心莲内酯琥珀酸半酯
• 英文名: 4-[[(1R,2R,4aS,5R,8aS)-2-(3-carboxypropanoyloxy)-1,4a-dimethyl-6-methylidene-5-[(2E)-2-(2-oxofuran-3-ylidene)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methoxy]-4-oxobutanoic acid
• 中文别名: 脱水穿心莲内酯二琥珀酸半酯; 脱水穿心莲内酯琥珀酸半酯(标准品); 脱水穿心莲内酯琥珀酸半酯/HPLC; 4-(((1R,2R,4,5R,8AS)-2-((3-羧基丙酰基)氧基)-1,4A-二甲基-6-亚甲基-5-((E)-2-(2-氧代-2,5-二氢呋喃-3-基)乙烯基)十氢萘-1-基)甲氧基)-4-氧代丁酸; Dehydroandroapholide Succinate :炎琥宁; 脱氢穿心莲内酯琥珀酸酯; 脱水穿心莲内酯琥珀酸半酯,10 MM DMSO 溶液; 穿心莲内酯杂质2; DEHYDROANDROAPHOLIDE SUCCINATE 脱水穿心莲内酯琥珀酸半酯; 脱水穿心莲内酯琥珀酸半酯(对照品)
• 英文别名: 4-(((1R,2R,4,5R,8aS)-2-((3-Cboxypropanoyl)oxy)-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)vinyl)decahydronaphthalen-1-yl)methoxy)-4-oxobutanoic acid; Dehydroandroapholide succite; Butanedioic acid, mono[[(1R,2R,4aR,5R,8aS)-2-(3-carboxy-1-oxopropoxy)-5-[(E)-2-(2,5-dihydro-2-oxo-3-furanyl)ethenyl]decahydro-1,4a-dimethyl-6-methylene-1-naphthalenyl]methyl] ester; 4-({(1R,2R,4aR,5R,8aS)-2-[(3-Carboxypropanoyl)oxy]-1,4a-dimethyl-6-methylene-5-[(E)-2-(2-oxo-2,5-dihydro-3-furanyl)vinyl]decahydro-1-naphthalenyl}methoxy)-4-oxobutanoic acid; DEHYDROANDROAPHOLIDESUCCINATE; Dehydroandroapholide Succinat; Dehydroandroapholide succinate, 10 mM in DMSO; Butanedioic acid 1-[[(1R,2R,4,5R,8aS)-2-(3-cboxy-1-oxopropoxy)-5-[(1E)-2-(2,5-dihydro-2-oxo-3-furanyl)ethenyl]decahydro-1,4a-dimethyl-6-methylene-1-naphthalenyl]methyl] ester; UNII-0X50BP49M1; Androapholide Impurity 2; 4-[[(1R,2R,4aS,5R,8aS)-2-(3-cboxypropanoyloxy)-1,4a-dimethyl-6-methylidene-5-[(2E)-2-(2-oxofuran-3-ylidene)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methoxy]-4-oxobutanoic acid; 14-Deoxy-11,12-didehydroandroapholide bis(hemisuccinate); 4-({(1R,2R,4aR,5R,8aS)-2-[(3-Carboxypropanoyl)oxy]-1,4a-dimethyl-6-methylene-5-[(E)-2-(2-oxo-2,5-dihydrofuran-3-yl)vinyl]decahydronaphthalen-1-yl}methoxy)-4-oxobutanoic acid

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 733.8±60.0 °C at 760 mmHg
• 熔点: 136-138ºC
• 分子式: C₂₈H₃₆O₁₀
• 分子量: 532.579
• 闪点: 239.1±26.4 °C
• 精确质量: 532.230835
• PSA: 153.50000
• LogP: 2.85
• 蒸汽压: 0.0±5.2 mmHg at 25°C
• 折射率: 1.562
• 储存条件: 2-8°C， 干燥

生物活性

• 描述: Dehydroandrographolide succinate,从中药穿心莲中提取,因其具有免疫刺激、抗感染和抗炎作用,被广泛应用于病毒性肺炎和病毒性上呼吸道感染的治疗。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenousadministration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6.

安全

• 危害码 (欧洲): Xi

合成路线

108-30-5 142037-79-4 ~92% 110-15-6 786593-06-4

文献：Luo, Xin-Feng; He, Ling; Yin, Hai-Bin; Zheng, Hu; Bei, Di; Deng, Jin-Jin; Huang, Wen-Cai Synthetic Communications, 2009 , vol. 39, # 19 p. 3444 - 3452

108-30-5 142037-79-4 ~93% 110-15-6 786593-06-4

文献：Luo, Xin-Feng; He, Ling; Yin, Hai-Bin; Zheng, Hu; Bei, Di; Deng, Jin-Jin; Huang, Wen-Cai Synthetic Communications, 2009 , vol. 39, # 19 p. 3444 - 3452

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