41743-41-3

• 常用中文名：原花青素A2
• 常用英文名：Procyanidin A2
• CAS号：41743-41-3
• 分子式：C₃₀H₂₄O₁₂
• 分子量：576.50
• 相关类别： 生物化工 天然产物
• 发布时间：2016-04-09 20:44:07
• 更新时间：2026-07-04 12:27:36
• Procyanidin A2 是存在于蔓越莓和越橘中的黄酮类物质,具有抗癌、抗氧化、抗菌及抗炎活性。

名称

• 中文名: 原花青素A2
• 英文名: proanthocyanidin A2
• 中文别名: 原花青素A2 标准品; 原花色素 A2; 原花青素 A2,10 MM DMSO 溶液; (2R,3R,8S,14R,15R)-2,8-双(3,4-二羟基苯基)-3,H,14H-8,14-甲桥苯并[7,8][1,3]二氧杂环己烯并[4,5-H]苯并吡喃-3,5,11,13,15-五醇
• 英文别名: Proanthocyanidin A2; (2r,3r,8s,14r,15r)-2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-2h,14h-8,14-methanochromeno[7,8-d][1,3]benzodioxocine-3,5,11,13,15-pentol; PROCYANIDIN A2 //BP; Proanthocyanidin A-2; 7,4beta-&Procyanidol A2; PROCYANIDIN A2; PROANTHOCYANIDIN A2;PROCYANIDIN A2; PROCYANIDOICATECHIN; Procyanidin Impurity 1; Procyanidoicatechin; 8)-epicatechin; Dimeric catechin; Procyanidin A2, 10 mM in DMSO; (2R,3R,8S,14R,15R)-2,8-Bis(3,4-dihydroxyphenyl)-3,4-dihydro-2H,14H-8,14-methanobenzo[7,8][1,3]dioxocino[4,5-h]chromene-3,5,11,13,15-pentaol; Procyanidin A2-RM; 8,14-Methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol, 2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3R,8S,14R,15R); Epicatechin-(2beta-&Procyanidin dimer A2; Procyanidin A2(P); PROCAINE HYDROCHLORIDE(RG)

物化性质

• 密度: 1.766g/cm3
• 沸点: 946ºC at 760 mmHg
• 分子式: C₃₀H₂₄O₁₂
• 分子量: 576.50
• 闪点: 525.9ºC
• 精确质量: 576.12700
• PSA: 209.76000
• LogP: 2.79350
• 外观性状: 粉末
• 折射率: 1.829
• 储存条件: 2-8°C

生物活性

• 描述: Procyanidin A2 是存在于蔓越莓和越橘中的黄酮类物质,具有抗癌、抗氧化、抗菌及抗炎活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Bacterial[1]

• 体外研究: 原花青素A2显示DPPH自由基清除活性,IC50为5.08±0.37μM[1]。
• 参考文献:

  [1]. LingrongWen, et al. Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities. Journal of Functional Foods. January 2014, 6, P: 555-563.

  [2]. Coleman SL, et al. Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells. Int J Mol Sci. 2016 Nov 12;17(11).

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport

合成路线

50562-99-7 ~% 41743-41-3

文献：Nonaka, Gen-ichiro; Morimoto, Satoshi; Nishioka, Itsuo Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2139 - 2145

139975-02-3 ~% 41743-41-3

文献：Balde, A. M.; Pieters, L. A.; Wray, V.; Kolodziej, H.; Berghe, D. A. Vanden; et al. Phytochemistry (Elsevier), 1991 , vol. 30, # 12 p. 4129 - 4136

139975-01-2 ~% 41743-41-3

文献：Balde, A. M.; Pieters, L. A.; Wray, V.; Kolodziej, H.; Berghe, D. A. Vanden; et al. Phytochemistry (Elsevier), 1991 , vol. 30, # 12 p. 4129 - 4136

29106-49-8 ~% 41743-41-3

文献：Kondo, Kazunari; Kurihara, Masaaki; Fukuhara, Kiyoshi; Tanaka, Takashi; Suzuki, Takashi; Miyata, Naoki; Toyoda, Masatake Tetrahedron Letters, 2000 , vol. 41, # 4 p. 485 - 488

88038-15-7 ~% 41743-41-3

文献：Nonaka, Gen-ichiro; Morimoto, Satoshi; Nishioka, Itsuo Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2139 - 2145

88082-60-4 ~% 41743-41-3

文献：Nonaka, Gen-ichiro; Morimoto, Satoshi; Nishioka, Itsuo Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2139 - 2145

114586-50-4 100-53-8 ~% 41743-41-3 50562-99-7

文献：Morimoto, Satoshi; Nonaka, Gen-ichiro; Nishioka, Itsuo Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 12 p. 4717 - 4729

114613-62-6 100-53-8 ~% 41743-41-3 37064-35-0

文献：Morimoto, Satoshi; Nonaka, Gen-ichiro; Nishioka, Itsuo Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 12 p. 4717 - 4729

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