156897-06-2

• 常用中文名：利克飞龙
• 常用英文名：Licofelone
• CAS号：156897-06-2
• 分子式：C₂₃H₂₂ClNO₂
• 分子量：379.879
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) COX 抑制剂
• 发布时间：2018-08-28 19:05:09
• 更新时间：2026-07-04 14:19:47
• Licofelone (ML-3000) 是双 COX/5-LOX 抑制剂,用于治疗骨关节炎。Licofelone (ML-3000) 具有抗炎和抗增殖作用。Licofelone (ML-3000) 诱导细胞凋亡,减少促炎性白三烯和前列腺素的产生。

名称

• 中文名: 利克飞龙
• 英文名: Licofelone
• 中文别名: 核黄素磷酸钠盐; 6-(4-氯苯基)-2,3-二氢-2,2-二甲基-7-苯基-1H-吡咯嗪-5-乙酸; 利克飞龙(纯度有争议); 化合物:Licofelone; 2-(6-(4-氯苯基)-2,2-二甲基-7-苯基-2,3-二氢-1H-吡咯嗪-5-基)乙酸; 2-[2-(4-氯苯基)-6,6-二甲基-1-苯基-5,7-二氢吡咯烷嗪-3-基]乙酸; 化合物：Licofelone; 利克飞龙,10 MM DMSO 溶液
• 英文别名: Licofelone, 10 mM in DMSO; 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl; 16-dihydrotanshinone I; ML-3000; Licofelone //BP; Licofelone, ML-3000; icofeL; 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid; 2-[2-(4-Chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid; 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid; Licofelone, >=; 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid; [6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid; [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 539.7±50.0 °C at 760 mmHg
• 熔点: 162-163ºC
• 分子式: C₂₃H₂₂ClNO₂
• 分子量: 379.879
• 闪点: 280.2±30.1 °C
• 精确质量: 379.133911
• PSA: 42.23000
• LogP: 6.73
• 外观性状: 淡黄色固体
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.627
• 储存条件: -20°C Freezer

生物活性

• 描述: Licofelone (ML-3000) 是双 COX/5-LOX 抑制剂,用于治疗骨关节炎。Licofelone (ML-3000) 具有抗炎和抗增殖作用。Licofelone (ML-3000) 诱导细胞凋亡,减少促炎性白三烯和前列腺素的产生。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> COX
  信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
• 参考文献:

  [1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.

  [2]. Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UY7759650 CHEMICAL NAME : 1H-Pyrrolizine-5-acetic acid, 2,3-dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl- CAS REGISTRY NUMBER : 156897-06-2 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C23-H22-Cl-N-O2 MOLECULAR WEIGHT : 379.91 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,159,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 mg/kg/11D-I TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from duodenum REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1329,1994

安全

• 危害码 (欧洲): Xi

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