微管蛋白聚合抑制剂结构式
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常用名 | 微管蛋白聚合抑制剂 | 英文名 | tubulin polymerization inhibitor |
|---|---|---|---|---|
| CAS号 | 564468-51-5 | 分子量 | 328.361 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 524.7±50.0 °C at 760 mmHg | |
| 分子式 | C22H16O3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 188.8±23.6 °C |
微管蛋白聚合抑制剂用途Tubulin polymetition-IN-24(化合物HMBA)是一种有效的微管蛋白聚合抑制剂。微管蛋白聚合-IN-24抑制MCF-7细胞增殖。微管蛋白聚合-IN-24在G2/M期诱导细胞凋亡和细胞周期阻滞。微管蛋白聚合-IN-24增加GTP水解速率并抑制微管组装[1]。 |
| 中文名 | 微管蛋白聚合抑制剂 |
|---|---|
| 英文名 | 10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone |
| 英文别名 | 更多 |
| 描述 | Tubulin polymetition-IN-24(化合物HMBA)是一种有效的微管蛋白聚合抑制剂。微管蛋白聚合-IN-24抑制MCF-7细胞增殖。微管蛋白聚合-IN-24在G2/M期诱导细胞凋亡和细胞周期阻滞。微管蛋白聚合-IN-24增加GTP水解速率并抑制微管组装[1]。 |
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| 相关类别 | |
| 体外研究 | 微管蛋白聚合-IN-24(化合物HMBA)以浓度依赖性方式抑制纯化微管蛋白(无MAPs)的组装[1]。24(0-100 nM)中的微管蛋白聚合以浓度依赖性方式抑制MCF-7增殖,IC50值为47 nM[1]。微管蛋白聚合-IN-24竞争性抑制秋水仙碱与微管蛋白的结合,Ki值为3.6μM[1]。微管蛋白聚合-IN-24在有丝分裂中抑制MCF-7细胞的进展,并诱导涉及p53途径的凋亡细胞死亡[1]。 |
| 参考文献 |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 524.7±50.0 °C at 760 mmHg |
| 分子式 | C22H16O3 |
| 分子量 | 328.361 |
| 闪点 | 188.8±23.6 °C |
| 精确质量 | 328.109955 |
| LogP | 3.80 |
| 蒸汽压 | 0.0±1.4 mmHg at 25°C |
| 折射率 | 1.700 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
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| 9(10H)-Anthracenone, 10-[(3-hydroxy-4-methoxyphenyl)methylene]- |
| 10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone |
| 10-(3-hydroxy-4-methoxybenzylidene)anthracen-9(10H)-one |
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