印楝素

• 常用名: 印楝素
• 英文名: Nimbin
• CAS号: 5945-86-8
• 分子量: 540.601
• 密度: 1.3±0.1 g/cm3
• 沸点: 606.1±55.0 °C at 760 mmHg
• 分子式: C₃₀H₃₆O₉
• 熔点: 197-199ºC (dec.)
• 闪点: 320.4±31.5 °C

印楝素用途

Nimbin 是一种从 Azadirachta 中分离的中间体柠檬苦素,可防止 tau 聚集并增加细胞活力。Nimbin 有效抑制登革病毒 (dengue virus) 的包膜蛋白。Nimbin 具有抗炎,解热,抗真菌,抗组胺,防腐,抗氧化剂,抗癌和抗病毒特性,并可以穿越血脑屏障。

印楝素名称

• 中文名: 印楝素
• 英文名: nimbin

印楝素生物活性

• 描述: Nimbin 是一种从 Azadirachta 中分离的中间体柠檬苦素,可防止 tau 聚集并增加细胞活力。Nimbin 有效抑制登革病毒 (dengue virus) 的包膜蛋白。Nimbin 具有抗炎,解热,抗真菌,抗组胺,防腐,抗氧化剂,抗癌和抗病毒特性,并可以穿越血脑屏障。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
  信号通路 >> 抗感染 >> 细菌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 参考文献:

  [1]. Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3(1):169-178.

  [2]. P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26(4):243-54.

  [3]. Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58(15):8545-52.

印楝素物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 606.1±55.0 °C at 760 mmHg
• 熔点: 197-199ºC (dec.)
• 分子式: C₃₀H₃₆O₉
• 分子量: 540.601
• 闪点: 320.4±31.5 °C
• 精确质量: 540.235962
• PSA: 118.34000
• LogP: 3.93
• InChIKey: NHOIBRJOQAYBJT-IMGVWCFESA-N
• SMILES: COC(=O)CC1C2(C)C3=C(C)C(c4ccoc4)CC3OC2C(OC(C)=O)C2C(C)(C(=O)OC)C=CC(=O)C21C
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 2-8C

印楝素安全信息

• 海关编码: 13021920

印楝素靶点实验

查看更多实验

实验名称：Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MT... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1776130

实验名称：Antifeedant activity against Reticulitermes speratus assessed as survival at 100 ug/d... 来源：ChEMBL 靶标：Reticulitermes speratus External Id：CHEMBL3059412

实验名称：Antifeedant activity against larvae of Spodoptera litura in castor leaves relative to... 来源：ChEMBL 靶标：Spodoptera litura External Id：CHEMBL3069882

实验名称：Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1776131

实验名称：Cytotoxicity against human CRL1579 cells assessed as cell viability after 48 hrs by M... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1776134

实验名称：Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by M... 来源：ChEMBL 靶标：SK-BR-3 External Id：CHEMBL1776133

实验名称：Antifeedant activity against Reticulitermes speratus assessed as survival at 400 ug/d... 来源：ChEMBL 靶标：Reticulitermes speratus External Id：CHEMBL3059406

实验名称：Antifeedant activity against Reticulitermes speratus assessed as survival at 500 ug/d... 来源：ChEMBL 靶标：Reticulitermes speratus External Id：CHEMBL3059407

实验名称：Tautomerase Activity Assay from Article 10.1074/jbc.M112.341321: "Novel Anti-inflamma... 来源：BindingDB 靶标：N/A External Id：BindingDB_5647_1

实验名称：Antifeedant activity against Reticulitermes speratus assessed as survival at 300 ug/d... 来源：ChEMBL 靶标：Reticulitermes speratus External Id：CHEMBL3059408

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印楝素英文别名

• Nimbin
• Methyl (2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-5-acetoxy-2-(3-furyl)-10-(2-methoxy-2-oxoethyl)-1,6,9a,10a-tetramethyl-9-oxo-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-2H-cyclopenta[b]naphtho[2,3-d]furan-6-carboxylate
• (4a,5a,6a,7a,15b,17a)-6-(Acetyloxy)-7,15:21,23-diepoxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid Dimethyl Ester
• methyl (2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-5-(acetyloxy)-2-(furan-3-yl)-10-(2-methoxy-2-oxoethyl)-1,6,9a,10a-tetramethyl-9-oxo-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-2H-cyclopenta[b]naphtho[2,3-d]furan-6-carboxylate