11-羟基柳杉酚

• 常用名: 11-羟基柳杉酚
• 英文名: 11,12-Dihydroxyabieta-8(14),9(11),12-trien-7-one
• CAS号: 88664-08-8
• 分子量: 316.43
• 密度: 1.1±0.1 g/cm3
• 沸点: 482.2±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₈O₃
• 熔点: 192-194 °C
• 闪点: 259.5±25.2 °C

11-羟基柳杉酚用途

11-羟基糖醇通过调节RARα和维生素D3受体(VDR)来调节细胞内受体的磺酰化[1]。

11-羟基柳杉酚名称

• 中文名: 11-羟基柳杉酚
• 英文名: 11,12-dihydroxyabieta-8,11,13-trien-7-one

11-羟基柳杉酚生物活性

• 描述: 11-羟基糖醇通过调节RARα和维生素D3受体(VDR)来调节细胞内受体的磺酰化[1]。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
• 靶点实验:

  RARα

• 参考文献:

  [1]. Meenaxi M. Maste, et al. Screening of Plectranthus amboinicus against COVID-19-in silico approach. J App Pharm Sci. 2020; 10(12): 90-97.

11-羟基柳杉酚物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 482.2±45.0 °C at 760 mmHg
• 熔点: 192-194 °C
• 分子式: C₂₀H₂₈O₃
• 分子量: 316.43
• 闪点: 259.5±25.2 °C
• 精确质量: 316.203857
• PSA: 57.53000
• LogP: 6.63
• InChIKey: GDLRDIDXYBIPFY-UHFFFAOYSA-N
• SMILES: CC(C)c1cc2c(c(O)c1O)C1(C)CCCC(C)(C)C1CC2=O
• 外观性状: 淡黄色结晶
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.556
• 储存条件: 2-8°C，干燥，密封

11-羟基柳杉酚安全信息

• 危害码 (欧洲): Xi

11-羟基柳杉酚靶点实验

查看更多实验

实验名称：Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 4... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4812858

实验名称：Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3428588

实验名称：Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4150383

实验名称：Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibiti... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL3428591

实验名称：Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3428589

实验名称：Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibiti... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL3428590

实验名称：Cytotoxicity against human HeLa cells in lag phase of growth after 48 hrs 来源：ChEMBL 靶标：HeLa External Id：CHEMBL3266207

实验名称：Cytotoxicity against human Hep2 cells in lag phase of growth after 48 hrs 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3266209

实验名称：Cytotoxicity against human HeLa cells in log phase of growth after 48 hrs 来源：ChEMBL 靶标：HeLa External Id：CHEMBL3266208

实验名称：Cytotoxicity against African green monkey Vero cells in lag phase of growth after 48 ... 来源：ChEMBL 靶标：Vero External Id：CHEMBL3266211

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11-羟基柳杉酚英文别名

• 12-O-DEMETHYLCRYPTOJAPANOL
• 11,12-Dihydroxyabieta-8(14),9(11),12-trien-7-one
• 11-Hydroxysugiol
• 11-hydroxy-sugiol