PYRIDINE-2-CARBOXAMIDE
PYRIDINE-2-CARBOXAMIDE structure
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Common Name | PYRIDINE-2-CARBOXAMIDE | ||
|---|---|---|---|---|
| CAS Number | 1452-77-3 | Molecular Weight | 122.125 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 257.7±32.0 °C at 760 mmHg | |
| Molecular Formula | C6H6N2O | Melting Point | 110 °C (dec.)(lit.) | |
| MSDS | USA | Flash Point | 109.7±25.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Quantification of Sorafenib in Human Serum by Competitive Enzyme-Linked Immunosorbent Assay.
Biol. Pharm. Bull. 38 , 1788-93, (2015) The multikinase inhibitor sorafenib has been used in the treatment of hepatocellular carcinoma, renal cell carcinoma, and differentiated thyroid carcinoma. Here we have demonstrated the production of the first specific antibody against sorafenib. Anti-sorafen... |
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Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors.
J. Neurosci. Res. 93 , 1592-9, (2015) Dopamine and acetylcholine are two principal transmitters in the striatum and are usually balanced to modulate local neural activity and to maintain striatal homeostasis. This study investigates the role of dopamine and muscarinic acetylcholine receptors in t... |
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Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers.
Nat. Commun. 6 , 8580, (2015) Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to the best of our knowledge, there are no reports on such mat... |
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Isolation of oxidative degradation products of atorvastatin with supercritical fluid chromatography.
Biomed. Chromatogr. 29 , 1901-6, (2015) The isolation of four oxidative degradation products of atorvastatin using preparative high-performance liquid chromatography applying at least two chromatographic steps is known from the literature. In this paper it is shown that the same four impurities cou... |
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First Novozym 435 lipase-catalyzed Morita-Baylis-Hillman reaction in the presence of amides.
Enzyme Microb. Technol. 84 , 32-40, (2016) The first Novozym 435 lipase-catalyzed Morita-Baylis-Hillman (MBH) reaction with amides as co-catalyst was realized. Results showed that neither Novozym 435 nor amide can independently catalyze the reaction. This co-catalytic system that used a catalytic amou... |
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14N NQR study of nicotinamide and related compounds.
Magn. Reson. Chem. 46(1) , 58-62, (2008) 14N nuclear quadrupole resonance (NQR) frequencies have been measured in picolinamide, nicotinamide, isonicotinamide, 2,6-pyridine dicarboxamide, and acetamide by double resonance. The 14N NQR spectra in picolinamide, nicotinamide, isonicotinamide, and 2,6-py... |
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Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.
J. Biol. Chem. 257(11) , 6084-8, (1982) We have shown previously that alloxan and streptozotocin, two major diabetogenic agents, cause DNA strand breaks in rat pancreatic islets and stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD level and inhibiting proinsulin sy... |
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Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide.
J. Pharmacol. Exp. Ther. 251(1) , 188-92, (1989) Nicotinamide is both a precursor for NAD synthesis and an inhibitor of intracellular NAD hydrolysing enzymes. Overnight treatment of rats with nicotinamide causes dose-dependent inhibition of the Na+/phosphate cotransporter in the renal brush border membrane.... |
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Interaction of nicotinamide and picolinamide with phosphatidylcholine and phosphatidylethanolamine membranes: a combined approach using dipole potential measurements and quantum chemical calculations.
Biochim. Biophys. Acta 1788(12) , 2553-62, (2009) Interaction between the bioactive compounds nicotinamide and picolinamide and phospholipids (phosphatidylcholines and phosphatidylethanolamines) was investigated by a combined approach using dipole potential measurements and quantum chemical calculations. It ... |
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New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.
Eur. J. Med. Chem. 47(1) , 520-9, (2012) N'-cyanopicolinamidine derivatives, linked to an arylpiperazine moiety, were prepared and their affinity to serotonin 5-HT(1A), 5-HT(2A) and 5-HT(2C) receptors were evaluated. The combination of structural elements (heterocyclic nucleus, alkyl chain and 4-sub... |